Seroatlas · Human Serome Atlas

REG1B

Lithostathine-1-beta

Also known as: PSPS2, REG1B_HUMAN, REGH, REGI-BETA, REGL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P48304
Gene: REG1B
Ensembl: ENSG00000172023
Chromosome: 2
Canonical length: 166 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to digestive system

OverviewNCBI Gene

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>P48304|REG1B
     1  MAQTNSFFML ISSLMFLSLS QGQESQTELP NPRISCPEGT NAYRSYCYYF NEDPETWVDA
    61  DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SSTDDSNVWI GLHDPKKNRR WHWSSGSLVS
   121  YKSWDTGSPS SANAGYCASL TSCSGFKKWK DESCEKKFSF VCKFKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REG1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 40,073 nTPM

Expression across tissuesHPA

Tissue

pancreas: 40,073 nTPM
small intestine: 2,688 nTPM
duodenum: 697 nTPM
smooth muscle: 105 nTPM
rectum: 101 nTPM
appendix: 34 nTPM

Single-cell type

pancreatic acinar cells: 32,647 nCPM
enterocytes: 2,975 nCPM
enteric transient amplifying cells: 255 nCPM
pancreatic duct cells: 106 nCPM
paneth cells: 77 nCPM
goblet cells: 42 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: -1.04
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REG1B as an antibody target. Whether an autoantibody or antibody against REG1B could matter depends on whether native REG1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REG1B is annotated as secreted, so native REG1B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label REG1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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