Seroatlas · Human Serome Atlas

CLEC18C

C-type lectin domain family 18 member C

Also known as: CL18C_HUMAN, MGC34761, MRCL3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCF0
Gene: CLEC18C
Ensembl: ENSG00000157335
Chromosome: 16
Canonical length: 446 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>Q8NCF0|CLEC18C
     1  MLHPETSPGR GHLLAVLLAL LGTAWAEVWP PQLQEQAPMA GALNRKESFL LLSLHNRLRS
    61  WVQPPAADMR RLDWSDSLAQ LAQARAALCG IPTPSLASGL WRTLQVGWNM QLLPAGLASF
   121  VEVVSLWFAE GQRYSHAAGE CARNATCTHY TQLVWATSSQ LGCGRHLCSA GQAAIEAFVC
   181  AYSPRGNWEV NGKTIVPYKK GAWCSLCTAS VSGCFKAWDH AGGLCEVPRN PCRMSCQNHG
   241  RLNISTCHCH CPPGYTGRYC QVRCSLQCVH GRFREEECSC VCDIGYGGAQ CATKVHFPFH
   301  TCDLRIDGDC FMVSSEADTY YRARMKCQRK GGVLAQIKSQ KVQDILAFYL GRLETTNEVI
   361  DSDFETRNFW IGLTYKTAKD SFRWATGEHQ AFTSFAFGQP DNHGFGNCVE LQASAAFNWN
   421  NQRCKTRNRY ICQFAQEHIS RWGPGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC18C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

kidney: 15 nTPM
testis: 3.3 nTPM
blood vessel: 0.3 nTPM
cerebellum: 0.2 nTPM
duodenum: 0.2 nTPM
thymus: 0.2 nTPM

Single-cell type

proximal tubule cells: 31 nCPM
sertoli cells: 9.8 nCPM
granulosa cells: 5.7 nCPM
retinal ganglion cells: 3.9 nCPM
podocytes: 2.8 nCPM
distal convoluted tubule cells: 1.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3.1 nTPM
cerebral cortex: 2.2 nTPM
basal ganglia: 1.4 nTPM
hippocampal formation: 1.1 nTPM
medulla oblongata: 1.1 nTPM
amygdala: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: 0.32

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

polysaccharide binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC18C as an antibody target. Whether an autoantibody or antibody against CLEC18C could matter depends on whether native CLEC18C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC18C is annotated as secreted, so native CLEC18C circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CLEC18C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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