Seroatlas · Human Serome Atlas

CLEC12B

C-type lectin domain family 12 member B

Also known as: CL12B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2HXU8
Gene: CLEC12B
Ensembl: ENSG00000256660
Chromosome: 12
Canonical length: 276 aa
Protein class: Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables protein phosphatase binding activity and signaling receptor inhibitor activity. Involved in several processes, including melanocyte proliferation; natural killer cell inhibitory signaling pathway; and regulation of signal transduction. Located in external side of plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>Q2HXU8|CLEC12B
     1  MSEEVTYATL TFQDSAGARN NRDGNNLRKR GHPAPSPIWR HAALGLVTLC LMLLIGLVTL
    61  GMMFLQISND INSDSEKLSQ LQKTIQQQQD NLSQQLGNSN NLSMEEEFLK SQISSVLKRQ
   121  EQMAIKLCQE LIIHTSDHRC NPCPKMWQWY QNSCYYFTTN EEKTWANSRK DCIDKNSTLV
   181  KIDSLEEKDF LMSQPLLMFS FFWLGLSWDS SGRSWFWEDG SVPSPSLFST KELDQINGSK
   241  GCAYFQKGNI YISRCSAEIF WICEKTAAPV KTEDLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC12B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
bone marrow: 5.2 nTPM
skin: 4.2 nTPM
spleen: 2.2 nTPM
lung: 0.9 nTPM
appendix: 0.5 nTPM

Single-cell type

melanocytes: 156 nCPM
sertoli cells: 78 nCPM
neutrophil progenitors: 25 nCPM
late spermatids: 17 nCPM
early spermatids: 15 nCPM
neutrophils: 13 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

midbrain: 0.4 nTPM
white matter: 0.4 nTPM
basal ganglia: 0.3 nTPM
hypothalamus: 0.3 nTPM
pons: 0.3 nTPM
cerebellum: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

C-type lectin-like
C-type lectin-like/link domain superfamily
C-type lectin fold
Natural killer cell receptor-like, C-type lectin-like domain
C-type lectin domain family 12 member A/B
Lectin C-type domain
Ly49-like, N-terminal
Ly49-like protein, N-terminal region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLEC12B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC12B as an antibody target. Whether an autoantibody or antibody against CLEC12B could matter depends on whether native CLEC12B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC12B is annotated at the cell surface, where native CLEC12B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC12B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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