Seroatlas · Human Serome Atlas

CLEC2B

C-type lectin domain family 2 member B

Also known as: AICL, CLC2B_HUMAN, CLECSF2, HP10085

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92478
Gene: CLEC2B
Ensembl: ENSG00000110852
Chromosome: 12
Canonical length: 149 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>Q92478|CLEC2B
     1  MMTKHKKCFI IVGVLITTNI ITLIVKLTRD SQSLCPYDWI GFQNKCYYFS KEEGDWNSSK
    61  YNCSTQHADL TIIDNIEEMN FLRRYKCSSD HWIGLKMAKN RTGQWVDGAT FTKSFGMRGS
   121  EGCAYLSDDG AATARCYTER KWICRKRIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 107 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 107 nTPM
skin: 76 nTPM
lung: 44 nTPM
spleen: 42 nTPM
ovary: 38 nTPM
adipose tissue: 36 nTPM

Single-cell type

neutrophils: 449 nCPM
nk-cells: 397 nCPM
t-cells: 343 nCPM
ocular epithelial cells: 335 nCPM
conjunctival goblet cells: 327 nCPM
kupffer cells: 229 nCPM

Immune cell

neutrophil: 223 nTPM
total PBMC: 84 nTPM
non-classical monocyte: 76 nTPM
memory CD8 T-cell: 70 nTPM
gdT-cell: 68 nTPM
NK-cell: 68 nTPM

Brain region

cerebral cortex: 13 nTPM
cerebellum: 12 nTPM
thalamus: 12 nTPM
choroid plexus: 11 nTPM
medulla oblongata: 11 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0.01
gnomAD missense Z: 0.6
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

NK T cell activation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLEC2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KLRF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC2B as an antibody target. Whether an autoantibody or antibody against CLEC2B could matter depends on whether native CLEC2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC2B is annotated at the cell surface, where native CLEC2B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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