Seroatlas · Human Serome Atlas

CLEC3A

C-type lectin domain family 3 member A

Also known as: CLC3A_HUMAN, CLECSF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75596
Gene: CLEC3A
Ensembl: ENSG00000166509
Chromosome: 16
Canonical length: 197 aa
Protein class: Predicted secreted proteins
Subcellular location: Endoplasmic reticulum
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

Predicted to enable carbohydrate binding activity. Predicted to be involved in ossification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>O75596|CLEC3A
     1  MAKNGLVICI LVITLLLDQT TSHTSRLKAR KHSKRRVRDK DGDLKTQIEK LWTEVNALKE
    61  IQALQTVCLR GTKVHKKCYL ASEGLKHFHE ANEDCISKGG ILVIPRNSDE INALQDYGKR
   121  SLPGVNDFWL GINDMVTEGK FVDVNGIAIS FLNWDRAQPN GGKRENCVLF SQSAQGKWSD
   181  EACRSSKRYI CEFTIPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 8.8 nTPM

Expression across tissuesHPA

Tissue

breast: 8.8 nTPM
urinary bladder: 5.4 nTPM
prostate: 1.9 nTPM
gallbladder: 1.4 nTPM
blood vessel: 1 nTPM
hypothalamus: 0.3 nTPM

Single-cell type

smooth muscle cells: 12 nCPM
podocytes: 9.3 nCPM
retinal amacrine cells: 5.6 nCPM
oocytes: 4.6 nCPM
myonuclei: 3.6 nCPM
epicardial cells: 2.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 8.1 nTPM
thalamus: 1.7 nTPM
medulla oblongata: 1.2 nTPM
pons: 0.6 nTPM
cerebral cortex: 0.3 nTPM
basal ganglia: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -2.65
DepMap mean gene effect: 0.21
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

carbohydrate binding

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC3A as an antibody target. Whether an autoantibody or antibody against CLEC3A could matter depends on whether native CLEC3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC3A is annotated as secreted, so native CLEC3A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CLEC3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...