Seroatlas · Human Serome Atlas

ATRN

Attractin

Also known as: ATRN_HUMAN, DPPT-L, MGCA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75882
Gene
ATRN
Ensembl
ENSG00000088812
Chromosome
20
Canonical length
1429 aa
Protein class
Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Cytosol
Secretome location
Secreted to blood
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

1429 residues, UniProt reviewed canonical sequence.

>O75882|ATRN
     1  MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP RLLSPPLRPR
    61  LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE CDRPCVNGGR CNPGTGQCVC
   121  PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG NYKYKTKCTW LIEGQPNRIM RLRFNHFATE
   181  CSWDHLYVYD GDSIYAPLVA AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG
   241  FNITYSFDMC PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN
   301  SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG NIMWVVGGYM
   361  FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY KDKIYMYGGK IDSTGNVTNE
   421  LRVFHIHNES WVLLTPKAKE QYAVVGHSAH IVTLKNGRVV MLVIFGHCPL YGYISNVQEY
   481  DLDKNTWSIL HTQGALVQGG YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD
   541  TQMWTILKDS RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW
   601  SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA HRSEAACLAA
   661  GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD HDRCDQHTDC YSCTANTNDC
   721  HWCNDHCVPR NHSCSEGQIS IFRYENCPKD NPMYYCNKKT SCRSCALDQN CQWEPRNQEC
   781  IALPENICGI GWHLVGNSCL KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR
   841  IMQSSQSMSK LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS
   901  TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM WCSNMKQCVD
   961  SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP GCGWCTDPSN TGKGKCIEGS
  1021  YKGPVKMPSQ APTGNFYPQP LLNSSMCLED SRYNWSFIHC PACQCNGHSK CINQSICEKC
  1081  ENLTTGKHCE TCISGFYGDP TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC
  1141  EVENRYQGNP LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS
  1201  KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN ITFFVYVSNF
  1261  TWPIKIQIAF SQHSNFMDLV QFFVTFFSCF LSLLLVAAVV WKIKQSCWAS RRREQLLREM
  1321  QQMASRPFAS VNVALETDEE PPDLIGGSIK TVPKPIALEP CFGNKAAVLS VFVRLPRGLG
  1381  GIPPPGQSGL AVASALVDIS QQMPIVYKEK SGAVRNRKQQ PPAQPGTCI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATRN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • liver: 59 nTPM
  • duodenum: 53 nTPM
  • parathyroid gland: 38 nTPM
  • small intestine: 31 nTPM
  • thyroid gland: 30 nTPM
  • stomach: 23 nTPM

Single-cell type

  • adrenal cortex cells: 328 nCPM
  • distal convoluted tubule cells: 285 nCPM
  • microglia: 222 nCPM
  • myonuclei: 198 nCPM
  • renal connecting tubule cells: 174 nCPM
  • macrophages: 152 nCPM

Immune cell

  • basophil: 3.7 nTPM
  • classical monocyte: 3.2 nTPM
  • non-classical monocyte: 3.1 nTPM
  • intermediate monocyte: 2.8 nTPM
  • myeloid DC: 2.8 nTPM
  • plasmacytoid DC: 2.6 nTPM

Brain region

  • white matter: 53 nTPM
  • cerebral cortex: 48 nTPM
  • hypothalamus: 47 nTPM
  • basal ganglia: 46 nTPM
  • spinal cord: 45 nTPM
  • hippocampal formation: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
2.69
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATRN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATRN as an antibody target. Whether an autoantibody or antibody against ATRN could matter depends on whether native ATRN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATRN is annotated at the cell surface, where native ATRN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ATRN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATRN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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