Seroatlas · Human Serome Atlas

OLR1

Oxidized low-density lipoprotein receptor 1

Also known as: CLEC8A, LOX-1, OLR1_HUMAN, SCARE1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78380
Gene
OLR1
Ensembl
ENSG00000173391
Chromosome
12
Canonical length
273 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>P78380|OLR1
     1  MTFDDLKIQT VKDQPDEKSN GKKAKGLQFL YSPWWCLAAA TLGVLCLGLV VTIMVLGMQL
    61  SQVSDLLTQE QANLTHQKKK LEGQISARQQ AEEASQESEN ELKEMIETLA RKLNEKSKEQ
   121  MELHHQNLNL QETLKRVANC SAPCPQDWIW HGENCYLFSS GSFNWEKSQE KCLSLDAKLL
   181  KINSTADLDF IQQAISYSSF PFWMGLSRRN PSYPWLWEDG SPLMPHLFRV RGAVSQTYPS
   241  GTCAYIQRGA VYAENCILAA FSICQKKANL RAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
107 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 107 nTPM
  • lung: 94 nTPM
  • spinal cord: 38 nTPM
  • appendix: 28 nTPM
  • bone marrow: 22 nTPM
  • cerebral cortex: 18 nTPM

Single-cell type

  • monocytes: 616 nCPM
  • cytotrophoblasts: 591 nCPM
  • syncytiotrophoblasts: 572 nCPM
  • microglia: 442 nCPM
  • macrophages: 318 nCPM
  • migrating cytotrophoblasts: 288 nCPM

Immune cell

  • myeloid DC: 2.8 nTPM
  • eosinophil: 1.3 nTPM
  • neutrophil: 1.3 nTPM
  • basophil: 0.7 nTPM
  • classical monocyte: 0.6 nTPM
  • total PBMC: 0.6 nTPM

Brain region

  • white matter: 115 nTPM
  • spinal cord: 63 nTPM
  • medulla oblongata: 57 nTPM
  • pons: 55 nTPM
  • thalamus: 52 nTPM
  • cerebellum: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0.01
gnomAD missense Z
0.55
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OLR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • HSP70

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OLR1 as an antibody target. Whether an autoantibody or antibody against OLR1 could matter depends on whether native OLR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OLR1 is annotated at the cell surface, where native OLR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OLR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OLR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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