Seroatlas · Human Serome Atlas

CD248

Endosialin

Also known as: CD164L1, CD248_HUMAN, TEM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HCU0
Gene
CD248
Ensembl
ENSG00000174807
Chromosome
11
Canonical length
757 aa
Protein class
CD markers, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Predicted to enable extracellular matrix binding activity and extracellular matrix protein binding activity. Predicted to be involved in cell migration. Predicted to act upstream of or within several processes, including fibroblast migration; lymph node development; and positive regulation of endothelial cell apoptotic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

757 residues, UniProt reviewed canonical sequence.

>Q9HCU0|CD248
     1  MLLRLLLAWA AAGPTLGQDP WAAEPRAACG PSSCYALFPR RRTFLEAWRA CRELGGDLAT
    61  PRTPEEAQRV DSLVGAGPAS RLLWIGLQRQ ARQCQLQRPL RGFTWTTGDQ DTAFTNWAQP
   121  ASGGPCPAQR CVALEASGEH RWLEGSCTLA VDGYLCQFGF EGACPALQDE AGQAGPAVYT
   181  TPFHLVSTEF EWLPFGSVAA VQCQAGRGAS LLCVKQPEGG VGWSRAGPLC LGTGCSPDNG
   241  GCEHECVEEV DGHVSCRCTE GFRLAADGRS CEDPCAQAPC EQQCEPGGPQ GYSCHCRLGF
   301  RPAEDDPHRC VDTDECQIAG VCQQMCVNYV GGFECYCSEG HELEADGISC SPAGAMGAQA
   361  SQDLGDELLD DGEDEEDEDE AWKAFNGGWT EMPGILWMEP TQPPDFALAY RPSFPEDREP
   421  QIPYPEPTWP PPLSAPRVPY HSSVLSVTRP VVVSATHPTL PSAHQPPVIP ATHPALSRDH
   481  QIPVIAANYP DLPSAYQPGI LSVSHSAQPP AHQPPMISTK YPELFPAHQS PMFPDTRVAG
   541  TQTTTHLPGI PPNHAPLVTT LGAQLPPQAP DALVLRTQAT QLPIIPTAQP SLTTTSRSPV
   601  SPAHQISVPA ATQPAALPTL LPSQSPTNQT SPISPTHPHS KAPQIPREDG PSPKLALWLP
   661  SPAPTAAPTA LGEAGLAEHS QRDDRWLLVA LLVPTCVFLV VLLALGIVYC TRCGPHAPNK
   721  RITDCYRWVI HAGSKSPTEP MPPRGSLTGV QTCRTSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD248 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
220 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 220 nTPM
  • breast: 146 nTPM
  • cervix: 76 nTPM
  • placenta: 63 nTPM
  • fallopian tube: 62 nTPM
  • vagina: 58 nTPM

Single-cell type

  • decidual stromal cells: 443 nCPM
  • fibroblasts: 146 nCPM
  • endometrial stromal cells: 120 nCPM
  • leydig cells: 85 nCPM
  • pericytes: 57 nCPM
  • hepatic stellate cells: 39 nCPM

Immune cell

  • naive CD8 T-cell: 22 nTPM
  • naive CD4 T-cell: 3.1 nTPM
  • memory CD8 T-cell: 2.6 nTPM
  • total PBMC: 2.5 nTPM
  • MAIT T-cell: 0.9 nTPM
  • gdT-cell: 0.2 nTPM

Brain region

  • thalamus: 6.7 nTPM
  • cerebral cortex: 5 nTPM
  • midbrain: 3.6 nTPM
  • basal ganglia: 3.3 nTPM
  • medulla oblongata: 3.2 nTPM
  • amygdala: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.06
gnomAD missense Z
1.21
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD248 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD248 as an antibody target. Whether an autoantibody or antibody against CD248 could matter depends on whether native CD248 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD248 is annotated at the cell surface, where native CD248 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD248 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD248. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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