Seroatlas · Human Serome Atlas

CLEC3B

Tetranectin

Also known as: TETN_HUMAN, TN, TNA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P05452
Gene
CLEC3B
Ensembl
ENSG00000163815
Chromosome
3
Canonical length
202 aa
Protein class
Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homotrimer

OverviewNCBI Gene

Enables calcium ion binding activity; heparin binding activity; and kringle domain binding activity. Involved in bone mineralization. Located in cytoplasm; extracellular space; and granular component. Implicated in osteoarthritis and retinal macular dystrophy 4. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>P05452|CLEC3B
     1  MELWGAYLLL CLFSLLTQVT TEPPTQKPKK IVNAKKDVVN TKMFEELKSR LDTLAQEVAL
    61  LKEQQALQTV CLKGTKVHMK CFLAFTQTKT FHEASEDCIS RGGTLGTPQT GSENDALYEY
   121  LRQSVGNEAE IWLGLNDMAA EGTWVDMTGA RIAYKNWETE ITAQPDGGKT ENCAVLSGAA
   181  NGKWFDKRCR DQLPYICQFG IV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
461 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 461 nTPM
  • heart muscle: 298 nTPM
  • spleen: 268 nTPM
  • breast: 243 nTPM
  • lung: 225 nTPM
  • skin: 166 nTPM

Single-cell type

  • ependymal cells: 121 nCPM
  • vascular endothelial cells: 37 nCPM
  • late spermatids: 29 nCPM
  • fibroblasts: 27 nCPM
  • leydig cells: 15 nCPM
  • epididymal clear cells: 12 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 53 nTPM
  • medulla oblongata: 45 nTPM
  • choroid plexus: 42 nTPM
  • thalamus: 41 nTPM
  • cerebral cortex: 35 nTPM
  • pons: 34 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLEC3B.

Disease | AllUniProt

Conditions CLEC3B is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 28 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Macular dystrophy, retinal, 4

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0
gnomAD missense Z
1.33
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC3B as an antibody target. Whether an autoantibody or antibody against CLEC3B could matter depends on whether native CLEC3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC3B is annotated as secreted, so native CLEC3B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CLEC3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLEC3B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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