LAYN
Layilin
Also known as: FLJ30977, FLJ31092, LAYN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UX15
- Gene
- LAYN
- Ensembl
- ENSG00000204381
- Chromosome
- 11
- Canonical length
- 382 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Enables hyaluronic acid binding activity. Located in focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
382 residues, UniProt reviewed canonical sequence.
>Q6UX15|LAYN
1 MRPGTALQAV LLAVLLVGLR AATGRLLSAS DLDLRGGQPV CRGGTQRPCY KVIYFHDTSR
61 RLNFEEAKEA CRRDGGQLVS IESEDEQKLI EKFIENLLPS DGDFWIGLRR REEKQSNSTA
121 CQDLYAWTDG SISQFRNWYV DEPSCGSEVC VVMYHQPSAP AGIGGPYMFQ WNDDRCNMKN
181 NFICKYSDEK PAVPSREAEG EETELTTPVL PEETQEEDAK KTFKESREAA LNLAYILIPS
241 IPLLLLLVVT TVVCWVWICR KRKREQPDPS TKKQHTIWPS PHQGNSPDLE VYNVIRKQSE
301 ADLAETRPDL KNISFRVCSG EATPDDMSCD YDNMAVNPSE SGFVTLVSVE SGFVTNDIYE
361 FSPDQMGRSK ESGWVENEIY GYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LAYN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 30 nTPM
- colon: 28 nTPM
- ovary: 27 nTPM
- thyroid gland: 26 nTPM
- smooth muscle: 21 nTPM
- seminal vesicle: 16 nTPM
Single-cell type
- lymphatic endothelial cells: 132 nCPM
- respiratory basal cells: 90 nCPM
- respiratory secretory cells: 84 nCPM
- alveolar cells type 1: 75 nCPM
- peritubular myoid cells: 52 nCPM
- respiratory deuterosomal cells: 46 nCPM
Immune cell
- T-reg: 13 nTPM
- myeloid DC: 11 nTPM
- memory CD4 T-cell: 0.5 nTPM
- naive CD8 T-cell: 0.4 nTPM
- total PBMC: 0.4 nTPM
- MAIT T-cell: 0.2 nTPM
Brain region
- white matter: 33 nTPM
- basal ganglia: 29 nTPM
- cerebral cortex: 26 nTPM
- midbrain: 26 nTPM
- thalamus: 22 nTPM
- medulla oblongata: 21 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.43
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.37
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LAYN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LAYN as an antibody target. Whether an autoantibody or antibody against LAYN could matter depends on whether native LAYN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LAYN is annotated at the cell surface, where native LAYN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label LAYN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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