Seroatlas · Human Serome Atlas

CLEC9A

C-type lectin domain family 9 member A

Also known as: CD370, CLC9A_HUMAN, DNGR-1, HEEE9341, UNQ9341

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXN8
Gene: CLEC9A
Ensembl: ENSG00000197992
Chromosome: 12
Canonical length: 241 aa
Protein class: CD markers, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>Q6UXN8|CLEC9A
     1  MHEEEIYTSL QWDSPAPDTY QKCLSSNKCS GACCLVMVIS CVFCMGLLTA SIFLGVKLLQ
    61  VSTIAMQQQE KLIQQERALL NFTEWKRSCA LQMKYCQAFM QNSLSSAHNS SPCPNNWIQN
   121  RESCYYVSEI WSIWHTSQEN CLKEGSTLLQ IESKEEMDFI TGSLRKIKGS YDYWVGLSQD
   181  GHSGRWLWQD GSSPSPGLLP AERSQSANQV CGYVKSNSLL SSNCSTWKYF ICEKYALRSS
   241  V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC9A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

lymph node: 7 nTPM
thymus: 4.6 nTPM
spleen: 4.5 nTPM
spinal cord: 4.1 nTPM
midbrain: 2.9 nTPM
testis: 2.8 nTPM

Single-cell type

microglia: 114 nCPM
cdc: 88 nCPM
hematopoietic stem cells: 50 nCPM
macrophages: 20 nCPM
late primary spermatocytes: 15 nCPM
early primary spermatocytes: 11 nCPM

Immune cell

myeloid DC: 22 nTPM
neutrophil: 7.9 nTPM
total PBMC: 0.4 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

medulla oblongata: 4.4 nTPM
white matter: 4 nTPM
spinal cord: 3.4 nTPM
hypothalamus: 3 nTPM
cerebellum: 2.9 nTPM
pons: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

carbohydrate binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

C-type lectin-like
C-type lectin-like/link domain superfamily
C-type lectin fold
C-type lectin, conserved site
Natural killer cell receptor-like, C-type lectin-like domain
Lectin C-type domain
C-type lectin domain family 9 member A

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC9A as an antibody target. Whether an autoantibody or antibody against CLEC9A could matter depends on whether native CLEC9A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC9A is annotated at the cell surface, where native CLEC9A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC9A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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