Seroatlas · Human Serome Atlas

ASGR2

Asialoglycoprotein receptor 2

Also known as: ASGR2_HUMAN, CLEC4H2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07307
Gene
ASGR2
Ensembl
ENSG00000161944
Chromosome
17
Canonical length
311 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Plasma membrane

OverviewNCBI Gene

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>P07307|ASGR2
     1  MAKDFQDIQQ LSSEENDHPF HQGEGPGTRR LNPRRGNPFL KGPPPAQPLA QRLCSMVCFS
    61  LLALSFNILL LVVICVTGSQ SEGHGGAQLQ AELRSLKEAF SNFSSSTLTE VQAISTHGGS
   121  VGDKITSLGA KLEKQQQDLK ADHDALLFHL KHFPVDLRFV ACQMELLHSN GSQRTCCPVN
   181  WVEHQGSCYW FSHSGKAWAE AEKYCQLENA HLVVINSWEE QKFIVQHTNP FNTWIGLTDS
   241  DGSWKWVDGT DYRHNYKNWA VTQPDNWHGH ELGGSEDCVE VQPDGRWNDD FCLQVYRWVC
   301  EKRRNATGEV A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASGR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
559 nTPM

Expression across tissuesHPA

Tissue

  • liver: 559 nTPM
  • gallbladder: 16 nTPM
  • appendix: 7.4 nTPM
  • bone marrow: 6.6 nTPM
  • skin: 4.9 nTPM
  • spleen: 4.4 nTPM

Single-cell type

  • hepatocytes: 951 nCPM
  • cholangiocytes: 149 nCPM
  • monocytes: 61 nCPM
  • epididymal efferent duct absorptive cells: 57 nCPM
  • monocyte progenitors: 45 nCPM
  • cdc: 14 nCPM

Immune cell

  • classical monocyte: 111 nTPM
  • myeloid DC: 65 nTPM
  • total PBMC: 32 nTPM
  • intermediate monocyte: 11 nTPM
  • neutrophil: 1.6 nTPM
  • plasmacytoid DC: 1.5 nTPM

Brain region

  • thalamus: 1.8 nTPM
  • cerebral cortex: 1.5 nTPM
  • choroid plexus: 1.5 nTPM
  • pons: 1.4 nTPM
  • white matter: 1.3 nTPM
  • medulla oblongata: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
0.29
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASGR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASGR2 as an antibody target. Whether an autoantibody or antibody against ASGR2 could matter depends on whether native ASGR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASGR2 is annotated at the cell surface, where native ASGR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ASGR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ASGR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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