Seroatlas · Human Serome Atlas

KLRF1

Killer cell lectin-like receptor subfamily F member 1

Also known as: CLEC5C, KLRF1_HUMAN, NKp80

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZS2
Gene: KLRF1
Ensembl: ENSG00000150045
Chromosome: 12
Canonical length: 231 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

231 residues, UniProt reviewed canonical sequence.

>Q9NZS2|KLRF1
     1  MQDEERYMTL NVQSKKRSSA QTSQLTFKDY SVTLHWYKIL LGISGTVNGI LTLTLISLIL
    61  LVSQGVLLKC QKGSCSNATQ YEDTGDLKVN NGTRRNISNK DLCASRSADQ TVLCQSEWLK
   121  YQGKCYWFSN EMKSWSDSYV YCLERKSHLL IIHDQLEMAF IQKNLRQLNY VWIGLNFTSL
   181  KMTWTWVDGS PIDSKIFFIK GPAKENSCAA IKESKIFSET CSSVFKWICQ Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLRF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

spleen: 17 nTPM
bone marrow: 12 nTPM
liver: 4.2 nTPM
lung: 4.1 nTPM
epididymis: 3.6 nTPM
tonsil: 3.3 nTPM

Single-cell type

nk-cells: 512 nCPM
t-cells: 33 nCPM
innate lymphoid cells: 12 nCPM
sertoli cells: 8.7 nCPM
cdc: 7.3 nCPM
cholangiocytes: 7.2 nCPM

Immune cell

NK-cell: 666 nTPM
MAIT T-cell: 95 nTPM
total PBMC: 83 nTPM
gdT-cell: 72 nTPM
naive CD8 T-cell: 36 nTPM
memory CD8 T-cell: 35 nTPM

Brain region

medulla oblongata: 0.8 nTPM
cerebral cortex: 0.7 nTPM
hypothalamus: 0.5 nTPM
pons: 0.5 nTPM
thalamus: 0.5 nTPM
amygdala: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLRF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CLEC2B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLRF1 as an antibody target. Whether an autoantibody or antibody against KLRF1 could matter depends on whether native KLRF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLRF1 is annotated at the cell surface, where native KLRF1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KLRF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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