Seroatlas · Human Serome Atlas

FCER2

Low affinity immunoglobulin epsilon Fc receptor

Also known as: CD23, CD23A, CLEC4J, FCE2, FcepsilonRII, FCER2_HUMAN, FCErII

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P06734
Gene: FCER2
Ensembl: ENSG00000104921
Chromosome: 19
Canonical length: 321 aa
Protein class: Cancer-related genes, CD markers, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>P06734|FCER2
     1  MEEGQYSEIE ELPRRRCCRR GTQIVLLGLV TAALWAGLLT LLLLWHWDTT QSLKQLEERA
    61  ARNVSQVSKN LESHHGDQMA QKSQSTQISQ ELEELRAEQQ RLKSQDLELS WNLNGLQADL
   121  SSFKSQELNE RNEASDLLER LREEVTKLRM ELQVSSGFVC NTCPEKWINF QRKCYYFGKG
   181  TKQWVHARYA CDDMEGQLVS IHSPEEQDFL TKHASHTGSW IGLRNLDLKG EFIWVDGSHV
   241  DYSNWAPGEP TSRSQGEDCV MMRGSGRWND AFCDRKLGAW VCDRLATCTP PASEGSAESM
   301  GPDSRPDPDG RLPTPSAPLH S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCER2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

tonsil: 40 nTPM
lymph node: 37 nTPM
spleen: 36 nTPM
appendix: 16 nTPM
small intestine: 9 nTPM
thymus: 5.9 nTPM

Single-cell type

b-cells: 116 nCPM
plasma cells: 6.2 nCPM
macrophages: 5.3 nCPM
innate lymphoid cells: 2.9 nCPM
foveolar cells: 2.7 nCPM
monocytes: 2.7 nCPM

Immune cell

naive B-cell: 497 nTPM
memory B-cell: 202 nTPM
total PBMC: 22 nTPM
intermediate monocyte: 15 nTPM
myeloid DC: 4.4 nTPM
non-classical monocyte: 4.4 nTPM

Brain region

cerebral cortex: 2.8 nTPM
hippocampal formation: 0.8 nTPM
cerebellum: 0.7 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
choroid plexus: 0.2 nTPM

ReferencesPubMed · IEDB

Publications for FCER2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Commensal Microbe-specific Activation of B2 Cell Subsets Contributes to Atherosclerosis Development Independently of Lipid Metabolism.
2016 · EBioMedicine · RCR 0.8 · 26 citations
Domain-specific anti-IgE antibodies interfere with IgE binding to Fc epsilon RII.
1994 · Int Arch Allergy Immunol · RCR 0.5 · 20 citations

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: -0.59
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCER2 as an antibody target. Whether an autoantibody or antibody against FCER2 could matter depends on whether native FCER2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCER2 is annotated at the cell surface, where native FCER2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FCER2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...