Seroatlas · Human Serome Atlas

ATRNL1

Attractin-like protein 1

Also known as: ALP, ATRN1_HUMAN, FLJ45344, KIAA0534

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VV63
Gene: ATRNL1
Ensembl: ENSG00000107518
Chromosome: 10
Canonical length: 1379 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable Notch binding activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1379 residues, UniProt reviewed canonical sequence.

>Q5VV63|ATRNL1
     1  METGGRARTG TPQPAAPGVW RARPAGGGGG GASSWLLDGN SWLLCYGFLY LALYAQVSQS
    61  KPCERTGSCF SGRCVNSTCL CDPGWVGDQC QHCQGRFKLT EPSGYLTDGP INYKYKTKCT
   121  WLIEGYPNAV LRLRFNHFAT ECSWDHMYVY DGDSIYAPLI AVLSGLIVPE IRGNETVPEV
   181  VTTSGYALLH FFSDAAYNLT GFNIFYSINS CPNNCSGHGK CTTSVSVPSQ VYCECDKYWK
   241  GEACDIPYCK ANCGSPDHGY CDLTGEKLCV CNDSWQGPDC SLNVPSTESY WILPNVKPFS
   301  PSVGRASHKA VLHGKFMWVI GGYTFNYSSF QMVLNYNLES SIWNVGTPSR GPLQRYGHSL
   361  ALYQENIFMY GGRIETNDGN VTDELWVFNI HSQSWSTKTP TVLGHGQQYA VEGHSAHIME
   421  LDSRDVVMII IFGYSAIYGY TSSIQEYHIS SNTWLVPETK GAIVQGGYGH TSVYDEITKS
   481  IYVHGGYKAL PGNKYGLVDD LYKYEVNTKT WTILKESGFA RYLHSAVLIN GAMLIFGGNT
   541  HNDTSLSNGA KCFSADFLAY DIACDEWKIL PKPNLHRDVN RFGHSAVVIN GSMYIFGGFS
   601  SVLLNDILVY KPPNCKAFRD EELCKNAGPG IKCVWNKNHC ESWESGNTNN ILRAKCPPKT
   661  AASDDRCYRY ADCASCTANT NGCQWCDDKK CISANSNCSM SVKNYTKCHV RNEQICNKLT
   721  SCKSCSLNLN CQWDQRQQEC QALPAHLCGE GWSHIGDACL RVNSSRENYD NAKLYCYNLS
   781  GNLASLTTSK EVEFVLDEIQ KYTQQKVSPW VGLRKINISY WGWEDMSPFT NTTLQWLPGE
   841  PNDSGFCAYL ERAAVAGLKA NPCTSMANGL VCEKPVVSPN QNARPCKKPC SLRTSCSNCT
   901  SNGMECMWCS STKRCVDSNA YIISFPYGQC LEWQTATCSP QNCSGLRTCG QCLEQPGCGW
   961  CNDPSNTGRG HCIEGSSRGP MKLIGMHHSE MVLDTNLCPK EKNYEWSFIQ CPACQCNGHS
  1021  TCINNNVCEQ CKNLTTGKQC QDCMPGYYGD PTNGGQCTAC TCSGHANICH LHTGKCFCTT
  1081  KGIKGDQCQL CDSENRYVGN PLRGTCYYSL LIDYQFTFSL LQEDDRHHTA INFIANPEQS
  1141  NKNLDISINA SNNFNLNITW SVGSTAGTIS GEETSIVSKN NIKEYRDSFS YEKFNFRSNP
  1201  NITFYVYVSN FSWPIKIQIA FSQHNTIMDL VQFFVTFFSC FLSLLLVAAV VWKIKQTCWA
  1261  SRRREQLLRE RQQMASRPFA SVDVALEVGA EQTEFLRGPL EGAPKPIAIE PCAGNRAAVL
  1321  TVFLCLPRGS SGAPPPGQSG LAIASALIDI SQQKASDSKD KTSGVRNRKH LSTRQGTCV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATRNL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 17 nTPM
testis: 11 nTPM
adrenal gland: 8.7 nTPM
ovary: 7.8 nTPM
blood vessel: 7.7 nTPM
hippocampal formation: 5.9 nTPM

Single-cell type

oligodendrocyte progenitor cells: 1,823 nCPM
adrenal cortex cells: 1,638 nCPM
retinal amacrine cells: 1,203 nCPM
retinal bipolar cells: 908 nCPM
brain excitatory neurons: 907 nCPM
brain inhibitory neurons: 810 nCPM

Immune cell

memory B-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 389 nTPM
white matter: 319 nTPM
basal ganglia: 175 nTPM
amygdala: 132 nTPM
hippocampal formation: 129 nTPM
thalamus: 125 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 1
gnomAD missense Z: 1.91
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATRNL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MC4R

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATRNL1 as an antibody target. Whether an autoantibody or antibody against ATRNL1 could matter depends on whether native ATRNL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATRNL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATRNL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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