REG4
Regenerating islet-derived protein 4
Also known as: GISP, REG-IV, REG4_HUMAN, RELP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BYZ8
- Gene
- REG4
- Ensembl
- ENSG00000134193
- Chromosome
- 1
- Canonical length
- 158 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
Enables heparin binding activity and mannan binding activity. Predicted to act upstream of or within response to bacterium. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
158 residues, UniProt reviewed canonical sequence.
>Q9BYZ8|REG4
1 MASRSMRLLL LLSCLAKTGV LGDIIMRPSC APGWFYHKSN CYGYFRKLRN WSDAELECQS
61 YGNGAHLASI LSLKEASTIA EYISGYQRSQ PIWIGLHDPQ KRQQWQWIDG AMYLYRSWSG
121 KSMGGNKHCA EMSSNNNFLT WSSNECNKRQ HFLCKYRPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against REG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 624 nTPM
Expression across tissuesHPA
Tissue
- small intestine: 624 nTPM
- rectum: 294 nTPM
- duodenum: 248 nTPM
- colon: 222 nTPM
- pancreas: 126 nTPM
- appendix: 32 nTPM
Single-cell type
- neuroendocrine cells: 5,724 nCPM
- goblet cells: 4,101 nCPM
- gastric progenitor cells: 569 nCPM
- foveolar cells: 81 nCPM
- pancreatic acinar cells: 78 nCPM
- late spermatids: 45 nCPM
Immune cell
- naive CD8 T-cell: 25 nTPM
- naive CD4 T-cell: 3.8 nTPM
- total PBMC: 2.5 nTPM
- memory CD8 T-cell: 1 nTPM
- neutrophil: 0.2 nTPM
- basophil: 0 nTPM
Brain region
- pons: 0.8 nTPM
- white matter: 0.7 nTPM
- cerebral cortex: 0.6 nTPM
- hypothalamus: 0.6 nTPM
- basal ganglia: 0.5 nTPM
- cerebellum: 0.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.25
- gnomAD pLI
- 0
- gnomAD missense Z
- 0
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads REG4 as an antibody target. Whether an autoantibody or antibody against REG4 could matter depends on whether native REG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
REG4 is annotated as secreted, so native REG4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label REG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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