HAPLN3
Hyaluronan and proteoglycan link protein 3
Also known as: EXLD1, HPLN3_HUMAN, HsT19883
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96S86
- Gene
- HAPLN3
- Ensembl
- ENSG00000140511
- Chromosome
- 15
- Canonical length
- 360 aa
- Protein class
- Predicted membrane proteins, Predicted secreted proteins
- Subcellular location
- Plasma membrane,Cytosol
- Secretome location
- Secreted to extracellular matrix
OverviewNCBI Gene
This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this gene may function in hyaluronic acid binding and cell adhesion. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
360 residues, UniProt reviewed canonical sequence.
>Q96S86|HAPLN3
1 MGLLLLVPLL LLPGSYGLPF YNGFYYSNSA NDQNLGNGHG KDLLNGVKLV VETPEETLFT
61 YQGASVILPC RYRYEPALVS PRRVRVKWWK LSENGAPEKD VLVAIGLRHR SFGDYQGRVH
121 LRQDKEHDVS LEIQDLRLED YGRYRCEVID GLEDESGLVE LELRGVVFPY QSPNGRYQFN
181 FHEGQQVCAE QAAVVASFEQ LFRAWEEGLD WCNAGWLQDA TVQYPIMLPR QPCGGPGLAP
241 GVRSYGPRHR RLHRYDVFCF ATALKGRVYY LEHPEKLTLT EAREACQEDD ATIAKVGQLF
301 AAWKFHGLDR CDAGWLADGS VRYPVVHPHP NCGPPEPGVR SFGFPDPQSR LYGVYCYRQHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HAPLN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 44 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 44 nTPM
- appendix: 11 nTPM
- lymph node: 11 nTPM
- adipose tissue: 11 nTPM
- lung: 11 nTPM
- breast: 9.1 nTPM
Single-cell type
- extravillous trophoblasts: 1,509 nCPM
- breast lactating cells: 291 nCPM
- rod photoreceptor cells: 128 nCPM
- breast secretory cells: 67 nCPM
- migrating cytotrophoblasts: 65 nCPM
- salivary myoepithelial cells: 60 nCPM
Immune cell
- T-reg: 51 nTPM
- memory CD4 T-cell: 18 nTPM
- naive CD4 T-cell: 18 nTPM
- NK-cell: 10 nTPM
- naive CD8 T-cell: 8.6 nTPM
- memory CD8 T-cell: 7.4 nTPM
Brain region
- pons: 2.2 nTPM
- thalamus: 2.1 nTPM
- medulla oblongata: 1.9 nTPM
- spinal cord: 1.8 nTPM
- amygdala: 1.4 nTPM
- cerebral cortex: 1.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.24
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.22
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HAPLN3 as an antibody target. Whether an autoantibody or antibody against HAPLN3 could matter depends on whether native HAPLN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HAPLN3 is annotated as secreted, so native HAPLN3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label HAPLN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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