Seroatlas · Human Serome Atlas

CLEC6A

C-type lectin domain family 6 member A

Also known as: CLC6A_HUMAN, CLECSF10, dectin-2, hDECTIN-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6EIG7
Gene: CLEC6A
Ensembl: ENSG00000205846
Chromosome: 12
Canonical length: 209 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>Q6EIG7|CLEC6A
     1  MMQEQQPQST EKRGWLSLRL WSVAGISIAL LSACFIVSCV VTYHFTYGET GKRLSELHSY
    61  HSSLTCFSEG TKVPAWGCCP ASWKSFGSSC YFISSEEKVW SKSEQNCVEM GAHLVVFNTE
   121  AEQNFIVQQL NESFSYFLGL SDPQGNNNWQ WIDKTPYEKN VRFWHLGEPN HSAEQCASIV
   181  FWKPTGWGWN DVICETRRNS ICEMNKIYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 1.1 nTPM

Expression across tissuesHPA

Tissue

appendix: 1.1 nTPM
lung: 1 nTPM
lymph node: 0.6 nTPM
tonsil: 0.3 nTPM
urinary bladder: 0.3 nTPM
bone marrow: 0.2 nTPM

Single-cell type

neutrophils: 3.5 nCPM
monocyte progenitors: 3.4 nCPM
monocytes: 3.4 nCPM
neutrophil progenitors: 2.7 nCPM
rod photoreceptor cells: 2.3 nCPM
epididymal clear cells: 2 nCPM

Immune cell

classical monocyte: 5.4 nTPM
myeloid DC: 2.2 nTPM
total PBMC: 1.5 nTPM
intermediate monocyte: 0.7 nTPM
neutrophil: 0.3 nTPM
basophil: 0 nTPM

Brain region

thalamus: 0.2 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC6A as an antibody target. Whether an autoantibody or antibody against CLEC6A could matter depends on whether native CLEC6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC6A is annotated at the cell surface, where native CLEC6A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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