Seroatlas · Human Serome Atlas

CLEC14A

C-type lectin domain family 14 member A

Also known as: C14orf27, CLC14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86T13
Gene
CLEC14A
Ensembl
ENSG00000176435
Chromosome
14
Canonical length
490 aa
Protein class
Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>Q86T13|CLEC14A
     1  MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA EEACILRGGA
    61  LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR SHCTLENEPL RGFSWLSSDP
   121  GGLESDTLQW VEEPQRSCTA RRCAVLQATG GVEPAGWKEM RCHLRANGYL CKYQFEVLCP
   181  APRPGAASNL SYRAPFQLHS AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG
   241  DVLCPCPGRY LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG
   301  VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG SQSTMSTLQM
   361  SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF IFVSTAVVVL VILTMTVLGL
   421  VKLCFHESPS SQPRKESMGP PGLESDPEPA ALGSSSAHCT NNGVKVGDCD LRDRAEGALL
   481  AESPLGSSDA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC14A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 70 nTPM
  • adipose tissue: 70 nTPM
  • lung: 57 nTPM
  • breast: 54 nTPM
  • tongue: 41 nTPM
  • endometrium: 34 nTPM

Single-cell type

  • vascular endothelial cells: 329 nCPM
  • lymphatic endothelial cells: 62 nCPM
  • hepatic stellate cells: 26 nCPM
  • oligodendrocyte progenitor cells: 11 nCPM
  • fibro-adipogenic progenitors: 9.3 nCPM
  • pericytes: 8.7 nCPM

Immune cell

  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • pons: 19 nTPM
  • white matter: 18 nTPM
  • medulla oblongata: 18 nTPM
  • thalamus: 18 nTPM
  • cerebellum: 15 nTPM
  • midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC14A as an antibody target. Whether an autoantibody or antibody against CLEC14A could matter depends on whether native CLEC14A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC14A is annotated at the cell surface, where native CLEC14A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC14A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLEC14A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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