Seroatlas · Human Serome Atlas

CLEC5A

C-type lectin domain family 5 member A

Also known as: CLC5A_HUMAN, CLECSF5, MDL-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NY25
Gene
CLEC5A
Ensembl
ENSG00000258227
Chromosome
7
Canonical length
188 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q9NY25|CLEC5A
     1  MNWHMIISGL IVVVLKVVGM TLFLLYFPQI FNKSNDGFTT TRSYGTVSQI FGSSSPSPNG
    61  FITTRSYGTV CPKDWEFYQA RCFFLSTSES SWNESRDFCK GKGSTLAIVN TPEKLKFLQD
   121  ITDAEKYFIG LIYHREEKRW RWINNSVFNG NVTNQNQNFN CATIGLTKTF DAASCDISYR
   181  RICEKNAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 39 nTPM
  • appendix: 6.9 nTPM
  • lung: 3.8 nTPM
  • choroid plexus: 3.7 nTPM
  • blood vessel: 2.7 nTPM
  • skin: 2.5 nTPM

Single-cell type

  • neutrophil progenitors: 67 nCPM
  • macrophages: 42 nCPM
  • cdc: 35 nCPM
  • monocytes: 24 nCPM
  • neutrophils: 23 nCPM
  • epicardial cells: 11 nCPM

Immune cell

  • classical monocyte: 9.1 nTPM
  • total PBMC: 1.8 nTPM
  • intermediate monocyte: 1.1 nTPM
  • neutrophil: 1.1 nTPM
  • myeloid DC: 0.4 nTPM
  • plasmacytoid DC: 0.2 nTPM

Brain region

  • thalamus: 9.7 nTPM
  • hypothalamus: 6.7 nTPM
  • midbrain: 5.6 nTPM
  • cerebral cortex: 4.9 nTPM
  • white matter: 4 nTPM
  • medulla oblongata: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0.13
gnomAD missense Z
0.24
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLEC5A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC5A as an antibody target. Whether an autoantibody or antibody against CLEC5A could matter depends on whether native CLEC5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC5A is annotated at the cell surface, where native CLEC5A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLEC5A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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