PRG2

Protein identityUniProt · HPA

UniProt accession

P13727

Gene

PRG2

Ensembl

ENSG00000186652

Chromosome

11

Canonical length

222 aa

Protein class

FDA approved drug targets, Plasma proteins, Predicted secreted proteins

Secretome location

Secreted in female reproductive system

OverviewNCBI Gene

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>P13727|PRG2
     1  MKLPLLLALL FGAVSALHLR SETSTFETPL GAKTLPEDEE TPEQEMEETP CRELEEEEEW
    61  GSGSEDASKK DGAVESISVP DMVDKNLTCP EEEDTVKVVG IPGCQTCRYL LVRSLQTFSQ
   121  AWFTCRRCYR GNLVSIHNFN INYRIQCSVS ALNQGQVWIG GRITGSGRCR RFQWVDGSRW
   181  NFAYWAAHQP WSRGGHCVAL CTRGGHWRRA HCLRRLPFIC SY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

2,458 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.27

gnomAD pLI

0

gnomAD missense Z

0.31

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• defense response to bacterium
• defense response to nematode
• immune response
• negative regulation of interleukin-10 production
• negative regulation of macrophage cytokine production
• positive regulation of interleukin-4 production

Molecular functions

• carbohydrate binding
• extracellular matrix structural constituent conferring compression resistance
• heparin binding

Cellular components

• extracellular exosome
• extracellular matrix
• extracellular region
• ficolin-1-rich granule lumen
• transport vesicle

Protein domainsUniProt · Pfam · InterPro

• C-type lectin-like
• Eosinophil major basic protein
• C-type lectin-like/link domain superfamily
• C-type lectin fold
• C-type lectin, conserved site
• Eosinophil major basic protein, C-type lectin-like domain
• C-type lectin and snaclec domain-containing protein
• Lectin C-type domain

KeywordsUniProt

• Antibiotic
• Antimicrobial
• Cytoplasmic vesicle
• Disulfide bond
• Glycoprotein
• Heparin-binding
• Immunity
• Lectin
• Nitration
• Proteoglycan
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of PRG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PAPPA