CLEC1B
C-type lectin domain family 1 member B
Also known as: CLC1B_HUMAN, CLEC-2, CLEC2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9P126
- Gene
- CLEC1B
- Ensembl
- ENSG00000165682
- Chromosome
- 12
- Canonical length
- 229 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
Canonical amino-acid sequenceUniProt
229 residues, UniProt reviewed canonical sequence.
>Q9P126|CLEC1B
1 MQDEDGYITL NIKTRKPALI SVGSASSSWW RVMALILLIL CVGMVVGLVA LGIWSVMQRN
61 YLQGENENRT GTLQQLAKRF CQYVVKQSEL KGTFKGHKCS PCDTNWRYYG DSCYGFFRHN
121 LTWEESKQYC TDMNATLLKI DNRNIVEYIK ARTHLIRWVG LSRQKSNEVW KWEDGSVISE
181 NMFEFLEDGK GNMNCAYFHN GKMHPTFCEN KHYLMCERKA GMTKVDQLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CLEC1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 75 nTPM
Expression across tissuesHPA
Tissue
- liver: 75 nTPM
- bone marrow: 9.1 nTPM
- spleen: 3.2 nTPM
- lung: 2.4 nTPM
- testis: 2.2 nTPM
- appendix: 0.8 nTPM
Single-cell type
- platelets: 1,200 nCPM
- megakaryocytes: 433 nCPM
- megakaryocyte progenitors: 53 nCPM
- kupffer cells: 42 nCPM
- vascular endothelial cells: 20 nCPM
- early spermatids: 9.7 nCPM
Immune cell
- total PBMC: 16 nTPM
- basophil: 16 nTPM
- eosinophil: 7.6 nTPM
- classical monocyte: 5.1 nTPM
- intermediate monocyte: 4.5 nTPM
- non-classical monocyte: 4.1 nTPM
Brain region
- hypothalamus: 2.3 nTPM
- medulla oblongata: 1.8 nTPM
- white matter: 1.8 nTPM
- pons: 1.7 nTPM
- cerebellum: 1.5 nTPM
- midbrain: 1.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.45
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.73
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CLEC1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CLEC1B as an antibody target. Whether an autoantibody or antibody against CLEC1B could matter depends on whether native CLEC1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CLEC1B is annotated at the cell surface, where native CLEC1B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CLEC1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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