Seroatlas · Human Serome Atlas

CD207

C-type lectin domain family 4 member K

Also known as: CLC4K_HUMAN, CLEC4K, Langerin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJ71
Gene
CD207
Ensembl
ENSG00000116031
Chromosome
2
Canonical length
328 aa
Protein class
CD markers, Disease related genes, Predicted membrane proteins
Subcellular location
Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q9UJ71|CD207
     1  MTVEKEAPDA HFTVDKQNIS LWPREPPPKS GPSLVPGKTP TVRAALICLT LVLVASVLLQ
    61  AVLYPRFMGT ISDVKTNVQL LKGRVDNIST LDSEIKKNSD GMEAAGVQIQ MVNESLGYVR
   121  SQFLKLKTSV EKANAQIQIL TRSWEEVSTL NAQIPELKSD LEKASALNTK IRALQGSLEN
   181  MSKLLKRQND ILQVVSQGWK YFKGNFYYFS LIPKTWYSAE QFCVSRNSHL TSVTSESEQE
   241  FLYKTAGGLI YWIGLTKAGM EGDWSWVDDT PFNKVQSVRF WIPGEPNNAG NNEHCGNIKA
   301  PSLQAWNDAP CDKTFLFICK RPYVPSEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD207 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
83 nTPM

Expression across tissuesHPA

Tissue

  • skin: 83 nTPM
  • esophagus: 17 nTPM
  • retina: 5.1 nTPM
  • small intestine: 4.6 nTPM
  • tonsil: 4.5 nTPM
  • spleen: 3.5 nTPM

Single-cell type

  • macrophages: 16 nCPM
  • cdc: 6.8 nCPM
  • retinal pigment epithelial cells: 4.3 nCPM
  • suprabasal keratinocytes: 2.2 nCPM
  • late spermatids: 2 nCPM
  • breast myoepithelial cells: 1.7 nCPM

Immune cell

  • myeloid DC: 1.1 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • choroid plexus: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD207.

Disease | AllUniProt

Conditions CD207 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0
gnomAD missense Z
0.02

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD207 as an antibody target. Whether an autoantibody or antibody against CD207 could matter depends on whether native CD207 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD207 is annotated at the cell surface, where native CD207 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD207 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD207. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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