Seroatlas · Human Serome Atlas

KLRC2

NKG2-C type II integral membrane protein

Also known as: CD159c, NKG2-C, NKG2C, NKG2C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P26717
Gene
KLRC2
Ensembl
ENSG00000205809
Chromosome
12
Canonical length
231 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

231 residues, UniProt reviewed canonical sequence.

>P26717|KLRC2
     1  MNKQRGTFSE VSLAQDPKRQ QRKPKGNKSS ISGTEQEIFQ VELNLQNPSL NHQGIDKIYD
    61  CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NFSPNTRTQK ARHCGHCPEE
   121  WITYSNSCYY IGKERRTWEE SLLACTSKNS SLLSIDNEEE MKFLASILPS SWIGVFRNSS
   181  HHPWVTINGL AFKHKIKDSD NAELNCAVLQ VNRLKSAQCG SSMIYHCKHK L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLRC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
9 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 9 nTPM
  • amygdala: 6.6 nTPM
  • hippocampal formation: 5.3 nTPM
  • spleen: 5.1 nTPM
  • hypothalamus: 4.9 nTPM
  • midbrain: 4.7 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 50 nCPM
  • nk-cells: 30 nCPM
  • t-cells: 12 nCPM
  • oligodendrocytes: 3.9 nCPM
  • innate lymphoid cells: 3 nCPM
  • bergmann glia: 0.6 nCPM

Immune cell

  • NK-cell: 85 nTPM
  • gdT-cell: 25 nTPM
  • memory CD8 T-cell: 11 nTPM
  • naive CD8 T-cell: 9.2 nTPM
  • total PBMC: 4.5 nTPM
  • MAIT T-cell: 0.5 nTPM

Brain region

  • white matter: 4.3 nTPM
  • midbrain: 3.5 nTPM
  • medulla oblongata: 3.4 nTPM
  • cerebral cortex: 3.3 nTPM
  • hypothalamus: 3.3 nTPM
  • pons: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.81
gnomAD pLI
0
gnomAD missense Z
-0.27
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLRC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLRC2 as an antibody target. Whether an autoantibody or antibody against KLRC2 could matter depends on whether native KLRC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLRC2 is annotated at the cell surface, where native KLRC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • They can also regulate specific humoral and cell-mediated immunity.

Canonical record: https://seroatlas.com/gene/KLRC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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