Seroatlas · Human Serome Atlas

CLEC4D

C-type lectin domain family 4 member D

Also known as: CD368, CLC4D_HUMAN, CLECSF8, Dectin-3, MCL, Mpcl

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXI8
Gene: CLEC4D
Ensembl: ENSG00000166527
Chromosome: 12
Canonical length: 215 aa
Protein class: CD markers, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>Q8WXI8|CLEC4D
     1  MGLEKPQSKL EGGMHPQLIP SVIAVVFILL LSVCFIASCL VTHHNFSRCK RGTGVHKLEH
    61  HAKLKCIKEK SELKSAEGST WNCCPIDWRA FQSNCYFPLT DNKTWAESER NCSGMGAHLM
   121  TISTEAEQNF IIQFLDRRLS YFLGLRDENA KGQWRWVDQT PFNPRRVFWH KNEPDNSQGE
   181  NCVVLVYNQD KWAWNDVPCN FEASRICKIP GTTLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC4D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 61 nTPM
appendix: 6.9 nTPM
spleen: 6.8 nTPM
cervix: 3 nTPM
lung: 3 nTPM
urinary bladder: 2.3 nTPM

Single-cell type

neutrophils: 201 nCPM
neutrophil progenitors: 132 nCPM
monocytes: 26 nCPM
monocyte progenitors: 15 nCPM
platelets: 5.7 nCPM
macrophages: 4.2 nCPM

Immune cell

neutrophil: 99 nTPM
classical monocyte: 57 nTPM
total PBMC: 12 nTPM
intermediate monocyte: 4.5 nTPM
myeloid DC: 2.4 nTPM
non-classical monocyte: 1.2 nTPM

Brain region

thalamus: 0.8 nTPM
choroid plexus: 0.6 nTPM
cerebral cortex: 0.4 nTPM
pons: 0.3 nTPM
medulla oblongata: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC4D as an antibody target. Whether an autoantibody or antibody against CLEC4D could matter depends on whether native CLEC4D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC4D is annotated at the cell surface, where native CLEC4D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLEC4D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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