CLEC2A
C-type lectin domain family 2 member A
Also known as: CLC2A_HUMAN, INPE5792, KACL, PILAR, UNQ5792
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UVW9
- Gene
- CLEC2A
- Ensembl
- ENSG00000188393
- Chromosome
- 12
- Canonical length
- 174 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Plasma membrane
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables protein homodimerization activity. Predicted to be involved in natural killer cell mediated cytotoxicity. Predicted to act upstream of or within several processes, including T cell receptor signaling pathway; regulation of actin filament polymerization; and regulation of interleukin-2 production. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
174 residues, UniProt reviewed canonical sequence.
>Q6UVW9|CLEC2A
1 MINPELRDGR ADGFIHRIVP KLIQNWKIGL MCFLSIIITT VCIIMIATWS KHAKPVACSG
61 DWLGVRDKCF YFSDDTRNWT ASKIFCSLQK AELAQIDTQE DMEFLKRYAG TDMHWIGLSR
121 KQGDSWKWTN GTTFNGWFEI IGNGSFAFLS ADGVHSSRGF IDIKWICSKP KYFLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CLEC2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 54 nTPM
Expression across tissuesHPA
Tissue
- skin: 54 nTPM
- breast: 3.3 nTPM
- epididymis: 0.5 nTPM
- vagina: 0.3 nTPM
- skeletal muscle: 0.2 nTPM
- cervix: 0.1 nTPM
Single-cell type
- suprabasal keratinocytes: 46 nCPM
- basal keratinocytes: 26 nCPM
- ocular epithelial cells: 16 nCPM
- oligodendrocytes: 3.7 nCPM
- respiratory ciliated cells: 3 nCPM
- fibroblasts: 2.7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 4.8 nTPM
- white matter: 1.7 nTPM
- pons: 1.5 nTPM
- medulla oblongata: 1.4 nTPM
- hypothalamus: 1.1 nTPM
- cerebral cortex: 1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.84
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.66
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CLEC2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CLEC2A as an antibody target. Whether an autoantibody or antibody against CLEC2A could matter depends on whether native CLEC2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CLEC2A is annotated at the cell surface, where native CLEC2A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CLEC2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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