C-type lectin-like/link domain superfamily
IPR016186
Definition
Lectins occur in plants, animals, bacteria and viruses. Initially described for their carbohydrate-binding activity PMID:14533786, they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions PMID:12223269. There are at least twelve structural families of lectins, of which C-type (Ca+-dependent) lectins is one. C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins PMID:15476922. The term 'C-type lectin domain' was introduced to distinguish a carbohydrate-recognition domain (CRD) which is present in all Ca2+-dependent lectins, but not in other types of animal lectins. However, there are proteins with modules similar in overall structure to CRDs that serve functions other than sugar binding. Therefore, a more general term C-type lectin-like domain was introduced to refer to such domains, although both terms are sometimes used interchangeably PMID:16336259. This superfamily represents a structural domain found in C-type lectins, as well as in other proteins, including: The C-terminal domain of invasin PMID:10514372 and intimin PMID:10890451. Link domain, which includes the Link module of tumor necrosis factor-inducible gene 6 protein (TSG-6) PMID:12972412 (a hyaladherin with important roles in inflammation and ovulation) and the hyaluronan binding domain of CD44 (which contains extra N-terminal β-strand and C-terminal β-hairpin) PMID:14992719. The Link domain may have emerged as a result of a deletion of the long loop region from an ancestral canonical C-type lectin domain PMID:8690089. Endostatin PMID:9724722 and the endostatin domain of collagen alpha 1 (XV) PMID:10966814, these domains being decorated with many insertions in the common fold.
100 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (100 proteins: gene, accession, name)
- ACAN
- ASGR1
- ASGR2
- ATRN
- ATRNL1
- BCAN
- CD207
- CD209
- CD248
- CD302
- CD44
- CD69
- CD72
- CD93
- CHODL
- CLEC10A
- CLEC11A
- CLEC12A
- CLEC12B
- CLEC14A
- CLEC17A
- CLEC18A
- CLEC18B
- CLEC18C
- CLEC19A
- CLEC1A
- CLEC1B
- CLEC20A
- CLEC2A
- CLEC2B
- CLEC2D
- CLEC2L
- CLEC3A
- CLEC3B
- CLEC4A
- CLEC4C
- CLEC4D
- CLEC4E
- CLEC4F
- CLEC4G
- CLEC4M
- CLEC5A
- CLEC6A
- CLEC7A
- CLEC9A
- CLECL1P
- COL15A1
- COL18A1
- COLEC10
- COLEC11
- COLEC12
- DGCR2
- FCER2
- FREM1
- HAPLN1
- HAPLN2
- HAPLN3
- HAPLN4
- KLRB1
- KLRC1
- KLRC2
- KLRC3
- KLRC4
- KLRD1
- KLRF1
- KLRF2
- KLRG1
- KLRG2
- KLRK1
- LAYN
- LY75
- LYVE1
- MBL2
- MRC1
- MRC2
- NCAN
- OLR1
- PKD1
- PKD1L2
- PKD1L3
- PLA2R1
- PRG2
- PRG3
- REG1A
- REG1B
- REG3A
- REG3G
- REG4
- SELE
- SELL
- SELP
- SFTPA1
- SFTPA2
- SFTPD
- STAB1
- STAB2
- SUSD5
- THBD
- TNFAIP6
- VCAN
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