SPRY domain
PF00622
Definition
SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development [[cite:PMID:9204703],[cite:PMID:17189197],[cite:PMID:23139046],[cite:PMID:27812363]]. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region PMID:17189197. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologues are domains in butyrophilin/ marenostrin/pyrin PMID:9204703.
93 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (93 proteins: gene, accession, name)
- ASH2L
- BSPRY
- BTN1A1
- BTN2A1
- BTN2A2
- BTN2A3P
- BTN3A1
- BTN3A3
- BTNL3
- BTNL8
- BTNL9
- CMYA5
- DDX1
- ERMAP
- FBXO45
- FSD1
- FSD1L
- FSD2
- HERC1
- HNRNPU
- HNRNPUL1
- HNRNPUL2
- MEFV
- MID1
- MID2
- RANBP10
- RANBP9
- RFPL1
- RFPL2
- RFPL3
- RFPL4A
- RFPL4AL1
- RFPL4B
- RNF123
- RNF135
- RNF39
- RSPRY1
- RYR1
- RYR2
- RYR3
- SPRYD3
- SPRYD4
- SPRYD7
- SPSB1
- SPSB2
- SPSB3
- SPSB4
- TRIM10
- TRIM11
- TRIM14
- TRIM15
- TRIM16
- TRIM16L
- TRIM17
- TRIM21
- TRIM22
- TRIM25
- TRIM26
- TRIM27
- TRIM34
- TRIM35
- TRIM38
- TRIM39
- TRIM4
- TRIM41
- TRIM43
- TRIM43B
- TRIM49
- TRIM49B
- TRIM49C
- TRIM49D1
- TRIM5
- TRIM50
- TRIM51
- TRIM51G
- TRIM58
- TRIM6
- TRIM60
- TRIM62
- TRIM64
- TRIM64B
- TRIM64C
- TRIM65
- TRIM67
- TRIM68
- TRIM69
- TRIM7
- TRIM72
- TRIM75
- TRIM77
- TRIM9
- TRIML1
- TRIML2
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