Seroatlas · Human Serome Atlas

TRIM69

E3 ubiquitin-protein ligase TRIM69

Also known as: RNF36, TRI69_HUMAN, Trif, TRIMLESS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86WT6
Gene
TRIM69
Ensembl
ENSG00000185880
Chromosome
15
Canonical length
500 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>Q86WT6|TRIM69
     1  MEVSTNPSSN IDPGDYVEMN DSITHLPSKV VIQDITMELH CPLCNDWFRD PLMLSCGHNF
    61  CEACIQDFWR LQAKETFCPE CKMLCQYNNC TFNPVLDKLV EKIKKLPLLK GHPQCPEHGE
   121  NLKLFSKPDG KLICFQCKDA RLSVGQSKEF LQISDAVHFF TEELAIQQGQ LETTLKELQT
   181  LRNMQKEAIA AHKENKLHLQ QHVSMEFLKL HQFLHSKEKD ILTELREEGK ALNEEMELNL
   241  SQLQEQCLLA KDMLVSIQAK TEQQNSFDFL KDITTLLHSL EQGMKVLATR ELISRKLNLG
   301  QYKGPIQYMV WREMQDTLCP GLSPLTLDPK TAHPNLVLSK SQTSVWHGDI KKIMPDDPER
   361  FDSSVAVLGS RGFTSGKWYW EVEVAKKTKW TVGVVRESII RKGSCPLTPE QGFWLLRLRN
   421  QTDLKALDLP SFSLTLTNNL DKVGIYLDYE GGQLSFYNAK TMTHIYTFSN TFMEKLYPYF
   481  CPCLNDGGEN KEPLHILHPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM69 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • testis: 34 nTPM
  • basal ganglia: 6.9 nTPM
  • cerebral cortex: 6.5 nTPM
  • skeletal muscle: 5.6 nTPM
  • tongue: 5.6 nTPM
  • amygdala: 5.4 nTPM

Single-cell type

  • brain inhibitory neurons: 30 nCPM
  • brain excitatory neurons: 28 nCPM
  • other brain neurons: 28 nCPM
  • choroid plexus epithelial cells: 26 nCPM
  • astrocytes: 24 nCPM
  • oligodendrocyte progenitor cells: 21 nCPM

Immune cell

  • T-reg: 4.3 nTPM
  • memory CD8 T-cell: 0.9 nTPM
  • memory CD4 T-cell: 0.8 nTPM
  • MAIT T-cell: 0.6 nTPM
  • memory B-cell: 0.6 nTPM
  • naive CD8 T-cell: 0.6 nTPM

Brain region

  • cerebral cortex: 4.4 nTPM
  • white matter: 3.1 nTPM
  • amygdala: 2.8 nTPM
  • basal ganglia: 2.8 nTPM
  • hypothalamus: 2.7 nTPM
  • medulla oblongata: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
-0.4
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM69 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM69 as an antibody target. Whether an autoantibody or antibody against TRIM69 could matter depends on whether native TRIM69 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM69 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM69 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM69. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...