Seroatlas · Human Serome Atlas

TRIM41

E3 ubiquitin-protein ligase TRIM41

Also known as: MGC1127, RINCK, TRI41_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WV44
Gene
TRIM41
Ensembl
ENSG00000146063
Chromosome
5
Canonical length
630 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

630 residues, UniProt reviewed canonical sequence.

>Q8WV44|TRIM41
     1  MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG EDEEDRDELD
    61  REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE EEEEGVFWTS GMSRSSWDNM
   121  DYVWEEEDEE EDLDYYLGDM EEEDLRGEDE EDEEEVLEEV EEEDLDPVTP LPPPPAPRRC
   181  FTCPQCRKSF PRRSFRPNLQ LANMVQVIRQ MHPTPGRGSR VTDQGICPKH QEALKLFCEV
   241  DEEAICVVCR ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT
   301  ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA SRLAEQAAQL
   361  SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EVQLQPPEVW SPDPCQPHSH DFLTDAIVRK
   421  MSRMFCQAAR VDLTLDPDTA HPALMLSPDR RGVRLAERRQ EVADHPKRFS ADCCVLGAQG
   481  FRSGRHYWEV EVGGRRGWAV GAARESTHHK EKVGPGGSSV GSGDASSSRH HHRRRRLHLP
   541  QQPLLQREVW CVGTNGKRYQ AQSSTEQTLL SPSEKPRRFG VYLDYEAGRL GFYNAETLAH
   601  VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
77 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 77 nTPM
  • midbrain: 64 nTPM
  • hippocampal formation: 41 nTPM
  • amygdala: 39 nTPM
  • basal ganglia: 39 nTPM
  • hypothalamus: 32 nTPM

Single-cell type

  • neutrophil progenitors: 40 nCPM
  • early primary spermatocytes: 36 nCPM
  • neutrophils: 29 nCPM
  • hepatocytes: 25 nCPM
  • megakaryocytes: 25 nCPM
  • kupffer cells: 22 nCPM

Immune cell

  • memory CD8 T-cell: 1.1 nTPM
  • neutrophil: 1 nTPM
  • MAIT T-cell: 0.9 nTPM
  • T-reg: 0.9 nTPM
  • naive CD8 T-cell: 0.8 nTPM
  • non-classical monocyte: 0.7 nTPM

Brain region

  • basal ganglia: 68 nTPM
  • midbrain: 67 nTPM
  • medulla oblongata: 65 nTPM
  • spinal cord: 63 nTPM
  • thalamus: 62 nTPM
  • white matter: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
1.01
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM41 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM41 as an antibody target. Whether an autoantibody or antibody against TRIM41 could matter depends on whether native TRIM41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM41. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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