Seroatlas · Human Serome Atlas

TRIM51G

Tripartite motif-containing protein 51G

Also known as: TR51G_HUMAN, TRIM51GP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A3B3IT33
Gene
TRIM51G
Ensembl
ENSG00000220948
Chromosome
11
Canonical length
452 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Vesicles

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>A0A3B3IT33|TRIM51G
     1  MNSGILQVFQ RELICPICMN YFIDPVTIDC GHSFCRPCFY LNWQDMAVLA QCSKCKKTTR
    61  QRNLKTNICL KNMASIARKA SLRQFLSSEE QICGTHRETK EMFCEVDKSL LCLLCSNSQE
   121  HRNHRHCPTE WAAEERREEL LRKMQSLWRK MCENHRNLNM ATNRIRCWKD YVSLRIEAIR
   181  AEYHKMVAFF HEEEQRHLER LQKEGEDIFQ QLNESKARME HSRELLRGMY EDLRQMCHKA
   241  VVELFQSFGD ILQRYESLLL QVSEPVNPEF SAGPIIGLMD RLKGFRVYLT LQHARASSHI
   301  FLHGDLRSMK VGCDPQHDPN ITDKSECFLQ WGADFFISGK FYWEFNMGHS WNWAFGVCNN
   361  YWKEKRQNDM IDGEVGLFLL GCVKEDTHCS LFTTSPLVMQ YVPRPTDTVG LFLDCEGRTV
   421  SFVDVDRSSL IYTIPNCSFS PPLWPIICCS HF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM51G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM
  • blood vessel: 0 nTPM

Single-cell type

  • late primary spermatocytes: 0.1 nCPM
  • late spermatids: 0.1 nCPM
  • neutrophil progenitors: 0.1 nCPM
  • undifferentiated spermatogonia: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM51G as an antibody target. Whether an autoantibody or antibody against TRIM51G could matter depends on whether native TRIM51G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM51G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM51G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM51G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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