Seroatlas · Human Serome Atlas

TRIM6

Tripartite motif-containing protein 6

Also known as: RNF89, TRIM6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C030
Gene
TRIM6
Ensembl
ENSG00000121236
Chromosome
11
Canonical length
488 aa
Protein class
Enzymes, Predicted intracellular proteins
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q9C030|TRIM6
     1  MTSPVLVDIR EEVTCPICLE LLTEPLSIDC GHSFCQACIT PNGRESVIGQ EGERSCPVCQ
    61  TSYQPGNLRP NRHLANIVRR LREVVLGPGK QLKAVLCADH GEKLQLFCQE DGKVICWLCE
   121  RSQEHRGHHT FLVEEVAQEY QEKFQESLKK LKNEEQEAEK LTAFIREKKT SWKNQMEPER
   181  CRIQTEFNQL RNILDRVEQR ELKKLEQEEK KGLRIIEEAE NDLVHQTQSL RELISDLERR
   241  CQGSTMELLQ DVSDVTERSE FWTLRKPEAL PTKLRSMFRA PDLKRMLRVC RELTDVQSYW
   301  VDVTLNPHTA NLNLVLAKNR RQVRFVGAKV SGPSCLEKHY DCSVLGSQHF SSGKHYWEVD
   361  VAKKTAWILG VCSNSLGPTF SFNHFAQNHS AYSRYQPQSG YWVIGLQHNH EYRAYEDSSP
   421  SLLLSMTVPP RRVGVFLDYE AGTVSFYNVT NHGFPIYTFS KYYFPTTLCP YFNPCNCVIP
   481  MTLRRPSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 20 nTPM
  • salivary gland: 9.9 nTPM
  • testis: 8.7 nTPM
  • placenta: 5 nTPM
  • smooth muscle: 4.9 nTPM
  • epididymis: 4.6 nTPM

Single-cell type

  • microglia: 3.5 nCPM
  • epicardial cells: 2.3 nCPM
  • ependymal cells: 1.6 nCPM
  • late primary spermatocytes: 1.3 nCPM
  • astrocytes: 1.2 nCPM
  • brain excitatory neurons: 0.6 nCPM

Immune cell

  • neutrophil: 1.2 nTPM
  • myeloid DC: 0.7 nTPM
  • eosinophil: 0.4 nTPM
  • NK-cell: 0.3 nTPM
  • basophil: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM

Brain region

  • medulla oblongata: 2.8 nTPM
  • choroid plexus: 2.4 nTPM
  • thalamus: 2.4 nTPM
  • hypothalamus: 2.2 nTPM
  • midbrain: 2.2 nTPM
  • spinal cord: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
-1.02
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM6 as an antibody target. Whether an autoantibody or antibody against TRIM6 could matter depends on whether native TRIM6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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