TRIM10

Protein identityUniProt · HPA

UniProt accession

Q9UDY6

Gene

TRIM10

Ensembl

ENSG00000204613

Chromosome

6

Canonical length

481 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>Q9UDY6|TRIM10
     1  MASAASVTSL ADEVNCPICQ GTLREPVTID CGHNFCRACL TRYCEIPGPD LEESPTCPLC
    61  KEPFRPGSFR PNWQLANVVE NIERLQLVST LGLGEEDVCQ EHGEKIYFFC EDDEMQLCVV
   121  CREAGEHATH TMRFLEDAAA PYREQIHKCL KCLRKEREEI QEIQSRENKR MQVLLTQVST
   181  KRQQVISEFA HLRKFLEEQQ SILLAQLESQ DGDILRQRDE FDLLVAGEIC RFSALIEELE
   241  EKNERPAREL LTDIRSTLIR CETRKCRKPV AVSPELGQRI RDFPQQALPL QREMKMFLEK
   301  LCFELDYEPA HISLDPQTSH PKLLLSEDHQ RAQFSYKWQN SPDNPQRFDR ATCVLAHTGI
   361  TGGRHTWVVS IDLAHGGSCT VGVVSEDVQR KGELRLRPEE GVWAVRLAWG FVSALGSFPT
   421  RLTLKEQPRQ VRVSLDYEVG WVTFTNAVTR EPIYTFTASF TRKVIPFFGL WGRGSSFSLS
   481  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

7.4 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.11

gnomAD pLI

0

gnomAD missense Z

-0.12

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• erythrocyte differentiation
• host-mediated suppression of symbiont invasion
• innate immune response

Molecular functions

• ubiquitin protein ligase activity
• zinc ion binding

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• B-box-type zinc finger
• Zinc finger, RING-type
• B30.2/SPRY domain
• SPRY domain
• Butyrophylin-like, SPRY domain
• SPRY-associated
• Zinc finger, RING/FYVE/PHD-type
• Concanavalin A-like lectin/glucanase domain superfamily
• Zinc finger, RING-type, conserved site
• Zinc finger, C3HC4 RING-type
• B30.2/SPRY domain superfamily
• Tripartite motif-containing
• Zinc finger, C3HC4 type (RING finger)
• SPRY domain
• B-box zinc finger
• SPRY-associated domain
• TRIM10, RING-HC finger

KeywordsUniProt

• Coiled coil
• Cytoplasm
• Metal-binding
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of TRIM10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IFNAR1