TRIM72

Protein identityUniProt · HPA

UniProt accession

Q6ZMU5

Gene

TRIM72

Ensembl

ENSG00000177238

Chromosome

16

Canonical length

477 aa

Protein class

Predicted intracellular proteins, Transporters

Subcellular location

Nucleoplasm,Vesicles

Quaternary structure

Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in several processes, including plasma membrane repair; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein homooligomerization. Predicted to act upstream of or within negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; and negative regulation of myotube differentiation. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in cytoplasm and sarcolemma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>Q6ZMU5|TRIM72
     1  MSAAPGLLHQ ELSCPLCLQL FDAPVTAECG HSFCRACLGR VAGEPAADGT VLCPCCQAPT
    61  RPQALSTNLQ LARLVEGLAQ VPQGHCEEHL DPLSIYCEQD RALVCGVCAS LGSHRGHRLL
   121  PAAEAHARLK TQLPQQKLQL QEACMRKEKS VAVLEHQLVE VEETVRQFRG AVGEQLGKMR
   181  VFLAALEGSL DREAERVRGE AGVALRRELG SLNSYLEQLR QMEKVLEEVA DKPQTEFLMK
   241  YCLVTSRLQK ILAESPPPAR LDIQLPIISD DFKFQVWRKM FRALMPALEE LTFDPSSAHP
   301  SLVVSSSGRR VECSEQKAPP AGEDPRQFDK AVAVVAHQQL SEGEHYWEVD VGDKPRWALG
   361  VIAAEAPRRG RLHAVPSQGL WLLGLREGKI LEAHVEAKEP RALRSPERRP TRIGLYLSFG
   421  DGVLSFYDAS DADALVPLFA FHERLPRPVY PFFDVCWHDK GKNAQPLLLV GPEGAEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM72 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

142 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for TRIM72 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.05

gnomAD pLI

0

gnomAD missense Z

1.45

DepMap mean gene effect

-0.16

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• exocytosis
• innate immune response
• muscle organ development
• muscle system process
• negative regulation of insulin receptor signaling pathway
• negative regulation of insulin-like growth factor receptor signaling pathway
• negative regulation of myotube differentiation
• plasma membrane repair
• proteasome-mediated ubiquitin-dependent protein catabolic process
• protein homooligomerization

Molecular functions

• identical protein binding
• mitogen-activated protein kinase kinase kinase binding
• phosphatidylserine binding
• ubiquitin conjugating enzyme binding
• ubiquitin protein ligase activity
• zinc ion binding

Cellular components

• cytoplasm
• cytoplasmic vesicle membrane
• sarcolemma

Protein domainsUniProt · Pfam · InterPro

• B-box-type zinc finger
• Zinc finger, RING-type
• B30.2/SPRY domain
• SPRY domain
• Butyrophylin-like, SPRY domain
• SPRY-associated
• Zinc finger, RING/FYVE/PHD-type
• Concanavalin A-like lectin/glucanase domain superfamily
• Zinc finger, RING-type, conserved site
• B30.2/SPRY domain superfamily
• Tripartite motif-containing
• SPRY domain
• B-box zinc finger
• SPRY-associated domain
• zinc finger of C3HC4-type, RING

KeywordsUniProt

• Cell membrane
• Coiled coil
• Cytoplasmic vesicle
• Disulfide bond
• Exocytosis
• Membrane
• Metal-binding
• Phosphoprotein
• S-nitrosylation
• Transferase
• Transport
• Ubl conjugation pathway
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of TRIM72 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CAV3
• DYSF