Seroatlas · Human Serome Atlas

BSPRY

B box and SPRY domain-containing protein

Also known as: BSPRY_HUMAN, FLJ20150

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5W0U4
Gene
BSPRY
Ensembl
ENSG00000119411
Chromosome
9
Canonical length
402 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cell leading edge; membrane; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q5W0U4|BSPRY
     1  MSAEGAEPGP GSGSGPGPGP LCPEHGQALS WFCGSERRPV CAACAGLGGR CRGHRIRRAE
    61  ERAEELRNKI VDQCERLQLQ SAAITKYVAD VLPGKNQRAV SMASAARELV IQRLSLVRSL
   121  CESEEQRLLE QVHGEEERAH QSILTQRVHW AEALQKLDTI RTGLVGMLTH LDDLQLIQKE
   181  QEIFERTEEA EGILDPQESE MLNFNEKCTR SPLLTQLWAT AVLGSLSGTE DIRIDERTVS
   241  PFLQLSDDRK TLTFSTKKSK ACADGPERFD HWPNALAATS FQNGLHAWMV NVQNSCAYKV
   301  GVASGHLPRK GSGSDCRLGH NAFSWVFSRY DQEFRFSHNG QHEPLGLLRG PAQLGVVLDL
   361  QVQELLFYEP ASGTVLCAHH VSFPGPLFPV FAVADQTISI VR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BSPRY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
421 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 421 nTPM
  • salivary gland: 77 nTPM
  • pancreas: 39 nTPM
  • esophagus: 29 nTPM
  • thyroid gland: 28 nTPM
  • skin: 25 nTPM

Single-cell type

  • esophageal apical cells: 260 nCPM
  • breast lactating cells: 174 nCPM
  • esophageal suprabasal cells: 155 nCPM
  • salivary acinar cells: 152 nCPM
  • breast hormone-responsive cells: 86 nCPM
  • breast secretory cells: 62 nCPM

Immune cell

  • plasmacytoid DC: 4.4 nTPM
  • gdT-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • basal ganglia: 24 nTPM
  • thalamus: 12 nTPM
  • cerebellum: 12 nTPM
  • midbrain: 10 nTPM
  • amygdala: 7.7 nTPM
  • cerebral cortex: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BSPRY in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BSPRY as an antibody target. Whether an autoantibody or antibody against BSPRY could matter depends on whether native BSPRY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BSPRY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BSPRY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BSPRY. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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