Seroatlas · Human Serome Atlas

TRIM49B

Putative tripartite motif-containing protein 49B

Also known as: TR49B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NDI0
Gene: TRIM49B
Ensembl: ENSG00000182053
Chromosome: 11
Canonical length: 452 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>A6NDI0|TRIM49B
     1  MNSGILQVFQ RELICPICMN YFIDPVTIDC GHSFCRPCFY LNWKDSPFLV QCSECTKSTG
    61  QINLKTNIHF KKMASLARKV SLWLFLSSEE QMCGTHRETK KMFCEVDRSL LCLLCSSSQE
   121  HRDHRHCPIE SAAEEHQEKL LQKMQSLWEK ACENHRNLNV ETTRTRCWKD YVNLRLEAIR
   181  AEYQKMPAFH HEEEKHNLEM LKKKGKDIFH RLHLSKAKMA HRREILRGMY EELNEMCHKP
   241  DVELLQAFGD ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANSDI
   301  FLCEILRSMC IGCDHQDVPY FTATPRSFLA WGAQTFTSGK YYWEVHVGDS WNWAFGVCNM
   361  YWKEKNQNEK IDGEDGLFLL GCVKNDIQRS LFTTSPLLLQ YIPRPTSRVG LFLDCEAKTV
   421  SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI HF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM49B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

retinal horizontal cells: 2 nCPM
early spermatids: 0.6 nCPM
mucous neck cells: 0.4 nCPM
undifferentiated spermatogonia: 0.4 nCPM
cardiomyocytes: 0.2 nCPM
brain excitatory neurons: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: -1.58
DepMap mean gene effect: -0.05
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM49B as an antibody target. Whether an autoantibody or antibody against TRIM49B could matter depends on whether native TRIM49B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM49B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM49B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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