Seroatlas · Human Serome Atlas

BTNL3

Butyrophilin-like protein 3

Also known as: BTN9.1, BTNL3_HUMAN, BTNLR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXE8
Gene: BTNL3
Ensembl: ENSG00000168903
Chromosome: 5
Canonical length: 466 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>Q6UXE8|BTNL3
     1  MAFVLILVLS FYELVSGQWQ VTGPGKFVQA LVGEDAVFSC SLFPETSAEA MEVRFFRNQF
    61  HAVVHLYRDG EDWESKQMPQ YRGRTEFVKD SIAGGRVSLR LKNITPSDIG LYGCWFSSQI
   121  YDEEATWELR VAALGSLPLI SIVGYVDGGI QLLCLSSGWF PQPTAKWKGP QGQDLSSDSR
   181  ANADGYSLYD VEISIIVQEN AGSILCSIHL AEQSHEVESK VLIGETFFQP SPWRLASILL
   241  GLLCGALCGV VMGMIIVFFK SKGKIQAELD WRRKHGQAEL RDARKHAVEV TLDPETAHPK
   301  LCVSDLKTVT HRKAPQEVPH SEKRFTRKSV VASQGFQAGK HYWEVDVGQN VGWYVGVCRD
   361  DVDRGKNNVT LSPNNGYWVL RLTTEHLYFT FNPHFISLPP STPPTRVGVF LDYEGGTISF
   421  FNTNDQSLIY TLLTCQFEGL LRPYIQHAMY DEEKGTPIFI CPVSWG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTNL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

duodenum: 109 nTPM
small intestine: 76 nTPM
colon: 24 nTPM
rectum: 23 nTPM
stomach: 1.6 nTPM
gallbladder: 1.5 nTPM

Single-cell type

enterocytes: 264 nCPM
colonocytes: 135 nCPM
goblet cells: 96 nCPM
enteric transient amplifying cells: 52 nCPM
paneth cells: 43 nCPM
enteric stem cells: 28 nCPM

Immune cell

neutrophil: 22 nTPM
classical monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 0.2 nTPM
pons: 0.2 nTPM
amygdala: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor binding

Cellular components

external side of plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTNL3 as an antibody target. Whether an autoantibody or antibody against BTNL3 could matter depends on whether native BTNL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTNL3 is annotated at the cell surface, where native BTNL3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BTNL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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