Seroatlas · Human Serome Atlas

TRIM38

E3 ubiquitin-protein ligase TRIM38

Also known as: RNF15, RORET, TRI38_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00635
Gene
TRIM38
Ensembl
ENSG00000112343
Chromosome
6
Canonical length
465 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cell Junctions,Centrosome

OverviewNCBI Gene

This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>O00635|TRIM38
     1  MASTTSTKKM MEEATCSICL SLMTNPVSIN CGHSYCHLCI TDFFKNPSQK QLRQETFCCP
    61  QCRAPFHMDS LRPNKQLGSL IEALKETDQE MSCEEHGEQF HLFCEDEGQL ICWRCERAPQ
   121  HKGHTTALVE DVCQGYKEKL QKAVTKLKQL EDRCTEQKLS TAMRITKWKE KVQIQRQKIR
   181  SDFKNLQCFL HEEEKSYLWR LEKEEQQTLS RLRDYEAGLG LKSNELKSHI LELEEKCQGS
   241  AQKLLQNVND TLSRSWAVKL ETSEAVSLEL HTMCNVSKLY FDVKKMLRSH QVSVTLDPDT
   301  AHHELILSED RRQVTRGYTQ ENQDTSSRRF TAFPCVLGCE GFTSGRRYFE VDVGEGTGWD
   361  LGVCMENVQR GTGMKQEPQS GFWTLRLCKK KGYVALTSPP TSLHLHEQPL LVGIFLDYEA
   421  GVVSFYNGNT GCHIFTFPKA SFSDTLRPYF QVYQYSPLFL PPPGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 14 nTPM
  • spleen: 13 nTPM
  • lymph node: 13 nTPM
  • bone marrow: 12 nTPM
  • appendix: 10 nTPM
  • kidney: 9.3 nTPM

Single-cell type

  • thymic myoid cells: 190 nCPM
  • neutrophils: 171 nCPM
  • b-cells: 164 nCPM
  • monocytes: 161 nCPM
  • monocyte progenitors: 140 nCPM
  • ocular epithelial cells: 140 nCPM

Immune cell

  • naive B-cell: 15 nTPM
  • memory B-cell: 13 nTPM
  • intermediate monocyte: 12 nTPM
  • basophil: 12 nTPM
  • non-classical monocyte: 12 nTPM
  • neutrophil: 11 nTPM

Brain region

  • choroid plexus: 8.2 nTPM
  • medulla oblongata: 7.7 nTPM
  • white matter: 7.1 nTPM
  • thalamus: 6.8 nTPM
  • pons: 6.7 nTPM
  • spinal cord: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.59
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM38 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM38 as an antibody target. Whether an autoantibody or antibody against TRIM38 could matter depends on whether native TRIM38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM38. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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