Seroatlas · Human Serome Atlas

RANBP10

Ran-binding protein 10

Also known as: KIAA1464, RBP10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6VN20
Gene: RANBP10
Ensembl: ENSG00000141084
Chromosome: 16
Canonical length: 620 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

620 residues, UniProt reviewed canonical sequence.

>Q6VN20|RANBP10
     1  MAAATADPGA GNPQPGDSSG GGAGGGLPSP GEQELSRRLQ RLYPAVNQQE TPLPRSWSPK
    61  DKYNYIGLSQ GNLRVHYKGH GKNHKDAASV RATHPIPAAC GIYYFEVKIV SKGRDGYMGI
   121  GLSAQGVNMN RLPGWDKHSY GYHGDDGHSF CSSGTGQPYG PTFTTGDVIG CCVNLINGTC
   181  FYTKNGHSLG IAFTDLPANL YPTVGLQTPG EIVDANFGQQ PFLFDIEDYM REWRAKVQGT
   241  VHCFPISARL GEWQAVLQNM VSSYLVHHGY CATATAFARM TETPIQEEQA SIKNRQKIQK
   301  LVLEGRVGEA IETTQRFYPG LLEHNPNLLF MLKCRQFVEM VNGTDSEVRS LSSRSPKSQD
   361  SYPGSPSLSP RHGPSSSHMH NTGADSPSCS NGVASTKSKQ NHSKYPAPSS SSSSSSSSSS
   421  SSPSSVNYSE SNSTDSTKSQ HHSSTSNQET SDSEMEMEAE HYPNGVLGSM STRIVNGAYK
   481  HEDLQTDESS MDDRHPRRQL CGGNQAATER IILFGRELQA LSEQLGREYG KNLAHTEMLQ
   541  DAFSLLAYSD PWSCPVGQQL DPIQREPVCA ALNSAILESQ NLPKQPPLML ALGQASECLR
   601  LMARAGLGSC SFARVDDYLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RANBP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 42 nTPM
liver: 30 nTPM
cerebellum: 27 nTPM
skeletal muscle: 24 nTPM
adrenal gland: 22 nTPM
spleen: 16 nTPM

Single-cell type

erythrocyte progenitors: 179 nCPM
myonuclei: 164 nCPM
choroid plexus epithelial cells: 100 nCPM
distal convoluted tubule cells: 90 nCPM
adrenal cortex cells: 89 nCPM
renal collecting duct intercalated cells: 84 nCPM

Immune cell

T-reg: 1 nTPM
eosinophil: 0.9 nTPM
MAIT T-cell: 0.9 nTPM
myeloid DC: 0.9 nTPM
naive CD8 T-cell: 0.8 nTPM
intermediate monocyte: 0.7 nTPM

Brain region

cerebellum: 23 nTPM
midbrain: 14 nTPM
cerebral cortex: 14 nTPM
amygdala: 14 nTPM
choroid plexus: 14 nTPM
hippocampal formation: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 1.55
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RANBP10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RANBP10 as an antibody target. Whether an autoantibody or antibody against RANBP10 could matter depends on whether native RANBP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RANBP10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RANBP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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