Seroatlas · Human Serome Atlas

TRIM77

Tripartite motif-containing protein 77

Also known as: TRI77_HUMAN, TRIM77P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: I1YAP6
Gene: TRIM77
Ensembl: ENSG00000214414
Chromosome: 11
Canonical length: 450 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>I1YAP6|TRIM77
     1  MASAITQCST SELTCSICTD YLTDPVTICC GHRFCSPCLC LLWEDTLTPN CCPVCREISQ
    61  QMYFKRIIFA EKQVIPTRES VPCQLSSSAM LICRRHQEIK NLICETDRSL LCFLCSQSPR
   121  HATHKHYMTR EADEYYRKKL LIQMKSIWKK KQKNQRNLNR ETNIIGTWEV FINLRSMMIS
   181  AEYPKVCQYL REEEQKHVES LAREGRIIFQ QLKRSQTRMA KMGILLREMY EKLKEMSCKA
   241  DVNLPQDLGD VMKRNEFLRL AMPQPVNPQL SAWTITGVSE RLNFFRVYIT LDRKICSNHK
   301  LLFEDLRHLQ CSLDDTDMSC NPTSTQYTSS WGAQILSSGK HYWEVDVKDS CNWVIGLCRE
   361  AWTKRNDMRL DSEGIFLLLC LKVDDHFSLF STSPLLPHYI PRPQGWLGVF LDYECGIVSF
   421  VNVAQSSLIC SFLSRIFYFP LRPFICHGSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM77 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

oocytes: 14 nCPM
foveolar cells: 0.6 nCPM
undifferentiated spermatogonia: 0.5 nCPM
brain excitatory neurons: 0.2 nCPM
early primary spermatocytes: 0.2 nCPM
mast cells: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.5 nTPM
white matter: 0.3 nTPM
basal ganglia: 0.2 nTPM
amygdala: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 1.22
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM77 as an antibody target. Whether an autoantibody or antibody against TRIM77 could matter depends on whether native TRIM77 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM77 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM77 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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