Seroatlas · Human Serome Atlas

TRIML1

Probable E3 ubiquitin-protein ligase TRIML1

Also known as: FLJ36180, RNF209, TRIML_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N9V2
Gene
TRIML1
Ensembl
ENSG00000184108
Chromosome
4
Canonical length
468 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>Q8N9V2|TRIML1
     1  MSTADLMENL REELTCFICL DYFSSPVTTE CGHSFCLVCL LRSWEEHNTP LSCPECWRTL
    61  EGPHFQSNER LGRLASIARQ LRSQVLQSED EQGSYGRMPT TAKALSDDEQ GGSAFVAQSH
   121  GANRVHLSSE AEEHHREKLQ EILNLLRVRR KEAQAVLTHE KERVKLCQEE TKTCKQVVVS
   181  EYMKMHQFLK EEEQLQLQLL EQEEKENMRK LRNNEIKLTQ QIRSLSKMIA QIESSSQSSA
   241  FESLEEVRGA LERSEPLLLQ CPEATTTELS LCRITGMKEM LRKFSTEITL DPATANAYLV
   301  LSEDLKSVKY GGSRQQLPDN PERFDQSATV LGTQIFTSGR HYWEVEVGNK TEWEVGICKD
   361  SVSRKGNLPK PPGDLFSLIG LKIGDDYSLW VSSPLKGQHV REPVCKVGVF LDYESGHIAF
   421  YNGTDESLIY SFPQASFQEA LRPIFSPCLP NEGTNTDPLT ICSLNSHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIML1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • testis: 11 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early spermatids: 190 nCPM
  • late primary spermatocytes: 44 nCPM
  • late spermatids: 36 nCPM
  • migrating cytotrophoblasts: 3.3 nCPM
  • cone photoreceptor cells: 2.1 nCPM
  • cytotrophoblasts: 1.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.37
gnomAD pLI
0
gnomAD missense Z
-0.41
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIML1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIML1 as an antibody target. Whether an autoantibody or antibody against TRIML1 could matter depends on whether native TRIML1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIML1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIML1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIML1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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