Seroatlas · Human Serome Atlas

TRIM67

Tripartite motif-containing protein 67

Also known as: TNL, TRI67_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZTA4
Gene: TRIM67
Ensembl: ENSG00000119283
Chromosome: 1
Canonical length: 783 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of protein localization. Predicted to act upstream of or within negative regulation of Ras protein signal transduction; positive regulation of neuron projection development; and positive regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

783 residues, UniProt reviewed canonical sequence.

>Q6ZTA4|TRIM67
     1  MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GEQHLPQPLL LSRGSGLQAG
    61  AAAAASLEHD AAAGPACGGA GGSAAGGLGG GAGGGGDHAD KLSLYSETDS GYGSYTPSLK
   121  SPNGVRVLPM VPAPPGSSAA AARGAACSSL SSSSSSITCP QCHRSASLDH RGLRGFQRNR
   181  LLEAIVQRYQ QGRGAVPGTS AAAAVAICQL CDRTPPEPAA TLCEQCDVLY CSACQLKCHP
   241  SRGPFAKHRL VQPPPPPPPP AEAASGPTGT AQGAPSGGGG CKSPGGAGAG ATGGSTARKF
   301  PTCPEHEMEN YSMYCVSCRT PVCYLCLEEG RHAKHEVKPL GAMWKQHKAQ LSQALNGVSD
   361  KAKEAKEFLV QLKNILQQIQ ENGLDYEACL VAQCDALVDA LTRQKAKLLT KVTKEREHKL
   421  KMVWDQINHC TLKLRQSTGL MEYCLEVIKE NDPSGFLQIS DALIKRVQVS QEQWVKGALE
   481  PKVSAEFDLT LDSEPLLQAI HQLDFIQMKC RVPPVPLLQL EKCCTRNNSV TLAWRMPPFT
   541  HSPVDGYILE LDDGAGGQFR EVYVGKETLC TIDGLHFNST YNARVKAFNS SGVGPYSKTV
   601  VLQTSDVAWF TFDPNSGHRD IILSNDNQTA TCSSYDDRVV LGTAAFSKGV HYWELHVDRY
   661  DNHPDPAFGV ARASVVKDMM LGKDDKAWAM YVDNNRSWFM HCNSHTNRTE GGVCKGATVG
   721  VLLDLNKHTL TFFINGQQQG PTAFSHVDGV FMPALSLNRN VQVTLHTGLE VPTNLGRPKL
   781  SGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM67 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 8.3 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.3 nTPM
cerebral cortex: 5 nTPM
retina: 3.1 nTPM
hypothalamus: 1.3 nTPM
midbrain: 1 nTPM
amygdala: 0.9 nTPM

Single-cell type

retinal horizontal cells: 92 nCPM
retinal amacrine cells: 51 nCPM
oligodendrocyte progenitor cells: 26 nCPM
retinal bipolar cells: 22 nCPM
brain inhibitory neurons: 21 nCPM
brain excitatory neurons: 13 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 17 nTPM
pons: 6.8 nTPM
medulla oblongata: 6.3 nTPM
midbrain: 4.3 nTPM
cerebral cortex: 4.2 nTPM
hypothalamus: 4.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRIM67.

Disease | ImmuneIEDB

Conditions an epitope on TRIM67 was assayed in.

encephalitis B cell
skin melanoma B cell

ReferencesPubMed · IEDB

Publications for TRIM67 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

TRIM9 and TRIM67 Are New Targets in Paraneoplastic Cerebellar Degeneration.
2019 · Cerebellum · RCR 2 · 43 citations
Detection of High-Risk Paraneoplastic Antibodies against TRIM9 and TRIM67 Proteins.
2023 · Ann Neurol · RCR 1.3 · 11 citations

Reference: B cellIEDB

1 publication

Detection of High-Risk Paraneoplastic Antibodies against TRIM9 and TRIM67 Proteins.
2023 · Ann Neurol · RCR 1.3 · 11 citations

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.97
gnomAD missense Z: 1.74
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM67 as an antibody target. Whether an autoantibody or antibody against TRIM67 could matter depends on whether native TRIM67 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM67 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM67 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...