Seroatlas · Human Serome Atlas

RFPL4AL1

Ret finger protein-like 4A-like protein 1

Also known as: RFAL1_HUMAN, RNF210B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
F8VTS6
Gene
RFPL4AL1
Ensembl
ENSG00000229292
Chromosome
19
Canonical length
287 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>F8VTS6|RFPL4AL1
     1  MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR FCSVVSQKDD
    61  IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF DVDTANNYLI ISEDLRSFRS
   121  GDLSQNRKEQ AERFDTALCV LGTPRFTSGR HYWEVDVGTS QVWDVGVCKE SVNRQGKIEL
   181  SSEHGFLTVG CREGKVFAAS TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHINT
   241  FIEIPVCEPW RPFFAHKRGS QDDQSILSIC SVINPSTASA PVSSEGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RFPL4AL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
0.6 nTPM

Expression across tissuesHPA

Tissue

  • liver: 0.6 nTPM
  • spleen: 0.3 nTPM
  • epididymis: 0.2 nTPM
  • testis: 0.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • undifferentiated spermatogonia: 0.8 nCPM
  • cdc: 0.7 nCPM
  • early spermatids: 0.6 nCPM
  • hepatocytes: 0.4 nCPM
  • peritubular myoid cells: 0.3 nCPM
  • sertoli cells: 0.3 nCPM

Immune cell

  • classical monocyte: 1.9 nTPM
  • myeloid DC: 0.8 nTPM
  • total PBMC: 0.7 nTPM
  • intermediate monocyte: 0.3 nTPM
  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • medulla oblongata: 0.6 nTPM
  • midbrain: 0.4 nTPM
  • cerebral cortex: 0.3 nTPM
  • spinal cord: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.47
gnomAD pLI
0.22
gnomAD missense Z
1.1

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RFPL4AL1 as an antibody target. Whether an autoantibody or antibody against RFPL4AL1 could matter depends on whether native RFPL4AL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RFPL4AL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RFPL4AL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RFPL4AL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...