Seroatlas · Human Serome Atlas

TRIM64B

Tripartite motif-containing protein 64B

Also known as: TR64B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NI03
Gene: TRIM64B
Ensembl: ENSG00000189253
Chromosome: 11
Canonical length: 449 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

449 residues, UniProt reviewed canonical sequence.

>A6NI03|TRIM64B
     1  MDSDDLQVFQ NELICCICVN YFIDPVTIDC GHSFCRPCLC LCSEEGRAPM RCPSCRKTSE
    61  KPNFNTNLVL KKLSSLARQT RPQNINSSDN ICVLHEETKE LFCEADKRLL CGPCSESPEH
   121  MAHSHSPIGW AAEECREKLI KEMDYLWEIN QETRNNLNQE TSTFHSLKDY VSVRKRIITI
   181  QYQKMPIFLD EEEQRHLQAL EREAEELFQQ LQDSQVRMTQ HLERMKDMYR ELWETCHMPD
   241  VVLLQDVRNV SARTDLAQMQ KPQPVNPELT SWCITGVLDM LNNFRVDSAL STEMIPCYIS
   301  LSEDVRYVIF GDDHLSAPTD PQGVDSFAVW GAQAFTSGKH YWEVDVTLSS NWILGVCRDS
   361  RTADANFVID SDERFFLISS KRSNHYSLST NSPPLIQYVQ RPLGRVGVFL DYDNGSVSFF
   421  DVSKGSLIYG FPPSSFSSPL RPFFCFGCT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM64B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 3.4 nTPM

Expression across tissuesHPA

Tissue

placenta: 3.4 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

extravillous trophoblasts: 0.8 nCPM
foveolar cells: 0.6 nCPM
sertoli cells: 0.6 nCPM
late spermatids: 0.3 nCPM
colonocytes: 0.1 nCPM
early spermatids: 0.1 nCPM

Immune cell

basophil: 84 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 1.34

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM64B as an antibody target. Whether an autoantibody or antibody against TRIM64B could matter depends on whether native TRIM64B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM64B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM64B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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