Seroatlas · Human Serome Atlas

TRIM34

E3 ubiquitin-protein ligase TRIM34

Also known as: RNF21, TRI34_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYJ4
Gene: TRIM34
Ensembl: ENSG00000258659
Chromosome: 11
Canonical length: 488 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoli,Centrosome
Quaternary structure: Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q9BYJ4|TRIM34
     1  MASKILLNVQ EEVTCPICLE LLTEPLSLDC GHSLCRACIT VSNKEAVTSM GGKSSCPVCG
    61  ISYSFEHLQA NQHLANIVER LKEVKLSPDN GKKRDLCDHH GEKLLLFCKE DRKVICWLCE
   121  RSQEHRGHHT VLTEEVFKEC QEKLQAVLKR LKKEEEEAEK LEADIREEKT SWKYQVQTER
   181  QRIQTEFDQL RSILNNEEQR ELQRLEEEEK KTLDKFAEAE DELVQQKQLV RELISDVECR
   241  SQWSTMELLQ DMSGIMKWSE IWRLKKPKMV SKKLKTVFHA PDLSRMLQMF RELTAVRCYW
   301  VDVTLNSVNL NLNLVLSEDQ RQVISVPIWP FQCYNYGVLG SQYFSSGKHY WEVDVSKKTA
   361  WILGVYCRTY SRHMKYVVRR CANRQNLYTK YRPLFGYWVI GLQNKCKYGV FEESLSSDPE
   421  VLTLSMAVPP CRVGVFLDYE AGIVSFFNVT SHGSLIYKFS KCCFSQPVYP YFNPWNCPAP
   481  MTLCPPSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

spleen: 13 nTPM
tonsil: 11 nTPM
lymph node: 11 nTPM
placenta: 9 nTPM
ovary: 8.7 nTPM
appendix: 8.6 nTPM

Single-cell type

microglia: 28 nCPM
ependymal cells: 4.1 nCPM
epicardial cells: 2.3 nCPM
astrocytes: 1.9 nCPM
bergmann glia: 1.7 nCPM
macrophages: 1 nCPM

Immune cell

intermediate monocyte: 21 nTPM
myeloid DC: 20 nTPM
neutrophil: 19 nTPM
classical monocyte: 19 nTPM
non-classical monocyte: 18 nTPM
naive B-cell: 16 nTPM

Brain region

medulla oblongata: 3.8 nTPM
white matter: 3.8 nTPM
spinal cord: 3.3 nTPM
hypothalamus: 3.2 nTPM
pons: 3 nTPM
midbrain: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: -0.14
DepMap mean gene effect: 0.25
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM34 as an antibody target. Whether an autoantibody or antibody against TRIM34 could matter depends on whether native TRIM34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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