Seroatlas · Human Serome Atlas

FSD1L

FSD1-like protein

Also known as: CCDC10, CSDUFD1, FSD1CL, FSD1L_HUMAN, FSD1NL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXM9
Gene
FSD1L
Ensembl
ENSG00000106701
Chromosome
9
Canonical length
530 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q9BXM9|FSD1L
     1  MDSQKYCFKE NENVTVDKAC FLISNITIGP ESINLQQEAL QRIISTLANK NDEIQNFIDT
    61  LHHTLKGVQE NSSNILSELD EEFDSLYSIL DEVKESMINC IKQEQARKSQ ELQSQISQCN
   121  NALENSEELL EFATRSLDIK EPEEFSKAAR QIKDRVTMAS AFRLSLKPKV SDNMTHLMVD
   181  FSQERQMLQT LKFLPVPKAP EIDPVECLVA DNSVTVAWRM PEEDNKIDHF ILEHRKTNFD
   241  GLPRVKDERC WEIIDNIKGT EYTLSGLKFD SKYMNFRVRA CNKAVAGEYS DPVTLETKAL
   301  NFNLDNSSSH LNLKVEDTCV EWDPTGGKGQ ESKIKGKENK GRSGTPSPKR TSVGSRPPAV
   361  RGSRDRFTGE SYTVLGDTAI ESGQHYWEVK AQKDCKSYSV GVAYKTLGKF DQLGKTNTSW
   421  CIHVNNWLQN TFAAKHNNKV KALDVTVPEK IGVFCDFDGG QLSFYDANSK QLLYSFKTKF
   481  TQPVLPGFMV WCGGLSLSTG MQVPSAVRTL QKSENGMTGS ASSLNNVVTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSD1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • retina: 40 nTPM
  • tongue: 12 nTPM
  • spinal cord: 11 nTPM
  • cerebral cortex: 11 nTPM
  • hypothalamus: 7.9 nTPM
  • midbrain: 7.1 nTPM

Single-cell type

  • cone photoreceptor cells: 849 nCPM
  • rod photoreceptor cells: 308 nCPM
  • gonadotrophs: 233 nCPM
  • ependymal cells: 214 nCPM
  • respiratory ciliated cells: 161 nCPM
  • fallopian tube ciliated cells: 149 nCPM

Immune cell

  • memory B-cell: 1.8 nTPM
  • classical monocyte: 0.9 nTPM
  • memory CD4 T-cell: 0.7 nTPM
  • naive B-cell: 0.7 nTPM
  • intermediate monocyte: 0.6 nTPM
  • myeloid DC: 0.6 nTPM

Brain region

  • medulla oblongata: 45 nTPM
  • hypothalamus: 42 nTPM
  • spinal cord: 41 nTPM
  • pons: 40 nTPM
  • white matter: 40 nTPM
  • midbrain: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FSD1L.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 66 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.23
gnomAD missense Z
1.52
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSD1L as an antibody target. Whether an autoantibody or antibody against FSD1L could matter depends on whether native FSD1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSD1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FSD1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FSD1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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