Seroatlas · Human Serome Atlas

TRIM17

E3 ubiquitin-protein ligase TRIM17

Also known as: RBCC, RNF16, terf, TRI17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y577
Gene
TRIM17
Ensembl
ENSG00000162931
Chromosome
1
Canonical length
477 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>Q9Y577|TRIM17
     1  MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK KGRRKRKGSF
    61  PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ EHHEPLKLFC QKDQSPICVV
   121  CRESREHRLH RVLPAEEAVQ GYKLKLEEDM EYLREQITRT GNLQAREEQS LAEWQGKVKE
   181  RRERIVLEFE KMNLYLVEEE QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE
   241  ERSTQGPLQM LQDMKEPLSR KNNVSVQCPE VAPPTRPRTV CRVPGQIEVL RGFLEDVVPD
   301  ATSAYPYLLL YESRQRRYLG SSPEGSGFCS KDRFVAYPCA VGQTAFSSGR HYWEVGMNIT
   361  GDALWALGVC RDNVSRKDRV PKCPENGFWV VQLSKGTKYL STFSALTPVM LMEPPSHMGI
   421  FLDFEAGEVS FYSVSDGSHL HTYSQATFPG PLQPFFCLGA PKSGQMVIST VTMWVKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 45 nTPM
  • testis: 39 nTPM
  • basal ganglia: 21 nTPM
  • cerebral cortex: 14 nTPM
  • hippocampal formation: 8 nTPM
  • spleen: 6 nTPM

Single-cell type

  • early spermatids: 351 nCPM
  • late spermatids: 101 nCPM
  • late primary spermatocytes: 98 nCPM
  • brain excitatory neurons: 13 nCPM
  • brain inhibitory neurons: 12 nCPM
  • ependymal cells: 8.8 nCPM

Immune cell

  • naive B-cell: 0.3 nTPM
  • eosinophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • cerebellum: 27 nTPM
  • basal ganglia: 19 nTPM
  • hippocampal formation: 16 nTPM
  • cerebral cortex: 14 nTPM
  • amygdala: 12 nTPM
  • hypothalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.07
gnomAD pLI
0
gnomAD missense Z
0.57
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM17 as an antibody target. Whether an autoantibody or antibody against TRIM17 could matter depends on whether native TRIM17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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