Seroatlas · Human Serome Atlas

RANBP9

Ran-binding protein 9

Also known as: RANB9_HUMAN, RanBPM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96S59
Gene: RANBP9
Ensembl: ENSG00000010017
Chromosome: 6
Canonical length: 729 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

729 residues, UniProt reviewed canonical sequence.

>Q96S59|RANBP9
     1  MSGQPPPPPP QQQQQQQQLS PPPPAALAPV SGVVLPAPPA VSAGSSPAGS PGGGAGGEGL
    61  GAAAAALLLH PPPPPPPATA APPPPPPPPP PPASAAAPAS GPPAPPGLAA GPGPAGGAPT
   121  PALVAGSSAA APFPHGDSAL NEQEKELQRR LKRLYPAVDE QETPLPRSWS PKDKFSYIGL
   181  SQNNLRVHYK GHGKTPKDAA SVRATHPIPA ACGIYYFEVK IVSKGRDGYM GIGLSAQGVN
   241  MNRLPGWDKH SYGYHGDDGH SFCSSGTGQP YGPTFTTGDV IGCCVNLINN TCFYTKNGHS
   301  LGIAFTDLPP NLYPTVGLQT PGEVVDANFG QHPFVFDIED YMREWRTKIQ AQIDRFPIGD
   361  REGEWQTMIQ KMVSSYLVHH GYCATAEAFA RSTDQTVLEE LASIKNRQRI QKLVLAGRMG
   421  EAIETTQQLY PSLLERNPNL LFTLKVRQFI EMVNGTDSEV RCLGGRSPKS QDSYPVSPRP
   481  FSSPSMSPSH GMNIHNLASG KGSTAHFSGF ESCSNGVISN KAHQSYCHSN KHQSSNLNVP
   541  ELNSINMSRS QQVNNFTSND VDMETDHYSN GVGETSSNGF LNGSSKHDHE MEDCDTEMEV
   601  DSSQLRRQLC GGSQAAIERM IHFGRELQAM SEQLRRDCGK NTANKKMLKD AFSLLAYSDP
   661  WNSPVGNQLD PIQREPVCSA LNSAILETHN LPKQPPLALA MGQATQCLGL MARSGIGSCA
   721  FATVEDYLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RANBP9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

testis: 100 nTPM
esophagus: 62 nTPM
bone marrow: 54 nTPM
skeletal muscle: 53 nTPM
tongue: 37 nTPM
vagina: 34 nTPM

Single-cell type

esophageal apical cells: 1,329 nCPM
neutrophils: 488 nCPM
neutrophil progenitors: 471 nCPM
pituicytes/fscs: 334 nCPM
respiratory deuterosomal cells: 288 nCPM
thymic myoid cells: 256 nCPM

Immune cell

T-reg: 3.6 nTPM
eosinophil: 1.8 nTPM
memory CD4 T-cell: 1.5 nTPM
MAIT T-cell: 1.4 nTPM
naive CD4 T-cell: 1.3 nTPM
NK-cell: 1.2 nTPM

Brain region

cerebral cortex: 47 nTPM
white matter: 43 nTPM
midbrain: 43 nTPM
basal ganglia: 42 nTPM
pons: 40 nTPM
hypothalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 1.49
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RANBP9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RANBP9 as an antibody target. Whether an autoantibody or antibody against RANBP9 could matter depends on whether native RANBP9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RANBP9 is annotated at the cell surface, where native RANBP9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RANBP9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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