Seroatlas · Human Serome Atlas

TRIM11

E3 ubiquitin-protein ligase TRIM11

Also known as: BIA1, RNF92, TRI11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96F44
Gene
TRIM11
Ensembl
ENSG00000154370
Chromosome
1
Canonical length
468 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>Q96F44|TRIM11
     1  MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP YACPECRELS
    61  PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCPAHREPLA AFCGDELRLL CAACERSGEH
   121  WAHRVRPLQD AAEDLKAKLE KSLEHLRKQM QDALLFQAQA DETCVLWQKM VESQRQNVLG
   181  EFERLRRLLA EEEQQLLQRL EEEELEVLPR LREGAAHLGQ QSAHLAELIA ELEGRCQLPA
   241  LGLLQDIKDA LRRVQDVKLQ PPEVVPMELR TVCRVPGLVE TLRRFRGDVT LDPDTANPEL
   301  ILSEDRRSVQ RGDLRQALPD SPERFDPGPC VLGQERFTSG RHYWEVEVGD RTSWALGVCR
   361  ENVNRKEKGE LSAGNGFWIL VFLGSYYNSS ERALAPLRDP PRRVGIFLDY EAGHLSFYSA
   421  TDGSLLFIFP EIPFSGTLRP LFSPLSSSPT PMTICRPKGG SGDTLAPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 61 nTPM
  • bone marrow: 29 nTPM
  • spleen: 23 nTPM
  • basal ganglia: 21 nTPM
  • esophagus: 20 nTPM
  • salivary gland: 17 nTPM

Single-cell type

  • early spermatids: 176 nCPM
  • syncytiotrophoblasts: 74 nCPM
  • esophageal apical cells: 61 nCPM
  • tuft cells: 35 nCPM
  • esophageal suprabasal cells: 28 nCPM
  • goblet cells: 27 nCPM

Immune cell

  • non-classical monocyte: 7.6 nTPM
  • memory CD8 T-cell: 7.1 nTPM
  • T-reg: 6.5 nTPM
  • memory CD4 T-cell: 6.4 nTPM
  • neutrophil: 6.2 nTPM
  • NK-cell: 6.2 nTPM

Brain region

  • cerebellum: 46 nTPM
  • basal ganglia: 29 nTPM
  • hippocampal formation: 26 nTPM
  • cerebral cortex: 24 nTPM
  • hypothalamus: 23 nTPM
  • amygdala: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.92
gnomAD missense Z
2.12
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM11 as an antibody target. Whether an autoantibody or antibody against TRIM11 could matter depends on whether native TRIM11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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