Seroatlas · Human Serome Atlas

TRIM27

Zinc finger protein RFP

Also known as: RFP, RNF76, TRI27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14373
Gene
TRIM27
Ensembl
ENSG00000204713
Chromosome
6
Canonical length
513 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli
Quaternary structure
Homomultimer

OverviewNCBI Gene

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>P14373|TRIM27
     1  MASGSVAECL QQETTCPVCL QYFAEPMMLD CGHNICCACL ARCWGTAETN VSCPQCRETF
    61  PQRHMRPNRH LANVTQLVKQ LRTERPSGPG GEMGVCEKHR EPLKLYCEED QMPICVVCDR
   121  SREHRGHSVL PLEEAVEGFK EQIQNQLDHL KRVKDLKKRR RAQGEQARAE LLSLTQMERE
   181  KIVWEFEQLY HSLKEHEYRL LARLEELDLA IYNSINGAIT QFSCNISHLS SLIAQLEEKQ
   241  QQPTRELLQD IGDTLSRAER IRIPEPWITP PDLQEKIHIF AQKCLFLTES LKQFTEKMQS
   301  DMEKIQELRE AQLYSVDVTL DPDTAYPSLI LSDNLRQVRY SYLQQDLPDN PERFNLFPCV
   361  LGSPCFIAGR HYWEVEVGDK AKWTIGVCED SVCRKGGVTS APQNGFWAVS LWYGKEYWAL
   421  TSPMTALPLR TPLQRVGIFL DYDAGEVSFY NVTERCHTFT FSHATFCGPV RPYFSLSYSG
   481  GKSAAPLIIC PMSGIDGFSG HVGNHGHSME TSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • liver: 58 nTPM
  • pancreas: 51 nTPM
  • spleen: 45 nTPM
  • prostate: 34 nTPM
  • pituitary gland: 34 nTPM
  • cervix: 31 nTPM

Single-cell type

  • microglia: 63 nCPM
  • choroid plexus epithelial cells: 47 nCPM
  • renal collecting duct intercalated cells: 41 nCPM
  • proximal tubule cells: 38 nCPM
  • renal connecting tubule cells: 33 nCPM
  • distal convoluted tubule cells: 33 nCPM

Immune cell

  • intermediate monocyte: 13 nTPM
  • MAIT T-cell: 11 nTPM
  • memory CD4 T-cell: 11 nTPM
  • total PBMC: 9.8 nTPM
  • myeloid DC: 8.7 nTPM
  • naive CD8 T-cell: 7.7 nTPM

Brain region

  • cerebral cortex: 4 nTPM
  • choroid plexus: 3.2 nTPM
  • medulla oblongata: 3.2 nTPM
  • midbrain: 3.1 nTPM
  • thalamus: 3 nTPM
  • white matter: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
gnomAD missense Z
3.7
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM27 as an antibody target. Whether an autoantibody or antibody against TRIM27 could matter depends on whether native TRIM27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM27. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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